Evidence map›Paper›PMID 31190121›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019

Bone mass density and bone metabolism marker are associated with progression of carotid and cardiac calcified plaque in Chinese elderly population.

D Liu, L Chen, S Dong, Z Peng, H Yang, Y Chen, L Li, H Zhou, R Zhou

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Low bone mineral density and coronary artery disease: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

D LiuTrauma Center, Daping Hospital, Third Military Medical University, Chongqing, China.
L ChenPostgraduate School, Bengbu Medical College, Bengbu, 233004, Anhui, China.
S DongPostgraduate School, Bengbu Medical College, Bengbu, 233004, Anhui, China.
Z PengDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
H YangDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
Y ChenDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
L LiDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
H ZhouDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.
R ZhouDepartment of Orthopedics, the Orthopedic Surgery Center of Chinese PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People's Republic of China. zhourui519@hotmail.com.
Army Medical University · CNBengbu Medical College · CNDaping Hospital · CN

Funding

Excellent Youth Fund of Third Military Medical University 2017YQRC-04National Natural Science Foundation of China 8160090461
6 · The paper itself

Abstract

Osteoporosis and cardiovascular diseases often coexist in the same elderly individuals. Does this suggest some potential correlation between the two diseases? Low bone mass and change of bone biomarker are associated with a higher risk of carotid and cardiac calcification plaques.

introductionBone mineral density (BMD) and bone metabolism marker may contribute to the progression of carotid and cardiac arterial calcifications. The aim of this study was to investigate whether low bone mass and the change of bone biomarker are associated with the prevalence of calcified atherosclerotic plaque in elderly Chinese.

methodsWe conducted a five-year prospective study. BMD was measured by dual-energy X-ray absorptiometry scanning. Carotid and cardiac computed tomography angiography (CTA) was conducted using a 64-multidetector row scanner to assess carotid and cardiac arterial plaque at baseline and during follow-up.

resultsOf 1571 community residents over 60 years of age, 184 (11.7%) subjects developed carotid calcified plaque, 510 (32.5%) subjects developed cardiac calcified plaque and 97 (6.2%) subjects developed co-existence calcified plaques in carotid and cardiac arteries. After adjustment for age and all relevant confounders, Q1, Q2 quartile of BMD, and osteoprotegerin (OPG), osteocalcin (OC), and C-terminal cross-linked telopeptide of type I collagen (CTX) were associated with increased risk of calcified plaques.

conclusionThis study suggested that lower BMD and change of bone metabolism biomarker were associated with a higher risk of carotid and cardiac calcified plaque development.

Indexed as

Absorptiometry, PhotonAgedAge DistributionAngiographyBiomarkersBone and BonesBone DensityCarotid StenosisChinaCoronary Artery DiseaseFemaleHumansMaleMiddle AgedOsteoporosisPlaque, AtheroscleroticBiomarkersBone metabolism markerBone mineral densityCalcified plaqueCardiac arteryCarotid artery

Identifiers

PMID31190121
OpenAlexW2951252596

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.