Evidence map›Paper›PMID 31190050›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium.

Maura Manion, Dimana Dimitrova, Luxin Pei, Juan Gea-Banacloche, Adrian Zelazny, Andrea Lisco, Christa Zerbe, Alexandra F Freeman, Steven M Holland, Christopher G Kanakry and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Prospective Study of a Novel, Radiation-Free, Reduced-Intensity Bone Marrow Transplantation Platform for Primary Immunodeficiency Diseases.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Trial
  2. Article
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  6. Open forum infectious diseases · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Maura ManionNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Dimana DimitrovaNational Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Luxin PeiNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Juan Gea-BanaclocheMayo Clinic, Phoenix, Arizona.
Adrian ZelaznyDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland.
Andrea LiscoNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Christa ZerbeNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Alexandra F FreemanNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Steven M HollandNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Christopher G KanakryNational Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Jennifer A KanakryNational Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Irini SeretiNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USMayo Clinic Hospital · US

Funding

Immunopathogenic Mechanisms of Human Immunodeficiency Virus (HIV) DiseaseZIAAI001121 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SERETI, IRINI · 2010 to 2025
$27.2M
Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Deciphering the efficacy of posttransplant cyclophosphamide in haplo transplantZIABC011659 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KANAKRY, CHRISTOPHER · 2015 to 2025
$18.5M
Primary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7M
6 · The paper itself

Abstract

Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

Indexed as

Hematopoietic Stem Cell TransplantationImmune Reconstitution Inflammatory SyndromeMycobacterium InfectionsPrimary Immunodeficiency DiseasesHumansMycobacterium aviumbone marrow transplantationimmune reconstitutionMycobacterium aviumprimary immunodeficiency

Identifiers

PMID31190050
PMCPMC7319264
OpenAlexW2949075486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.