Evidence map›Paper›PMID 31189985›Full record

Trial reportScientific reports2019

Theta band high definition transcranial alternating current stimulation, but not transcranial direct current stimulation, improves associative memory performance.

Stefan Lang, Liu Shi Gan, Tazrina Alrazi, Oury Monchi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05805215 (Noninvasive Temporal Interference Stimulation), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05805215 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Noninvasive Temporal Interference Stimulation: An Approach for Modulating Associative Memory by Targeting Deep-brain Targets

TypeinterventionalSponsorMasaryk UniversityRan2024 to 2025Enrolled30ConditionsHealthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment, Alzheimer DiseaseArmsNon-invasive Temporal Interference stimulation and Face-name association training task targeting the hippocampus, Non-invasive Temporal Interference stimulation and Face-name association training task targeting the Precuneus, High-frequency stimulation (placebo) with Face-name association training task
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Transcranial Alternating Current Stimulation (tACS) and Its Role in Schizophrenia: A Scoping Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stefan LangHotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada.
Liu Shi GanHotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada.
Tazrina AlraziHotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada.
Oury MonchiHotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada. oury.monchi@ucalgary.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Associative memory (AM) deficits are common in neurodegenerative disease and novel therapies aimed at improving these faculties are needed. Theta band oscillations within AM networks have been shown to be important for successful memory encoding and modulating these rhythms represents a promising strategy for cognitive enhancement. Transcranial alternating current stimulation (TACS) has been hypothesized to entrain and increase power of endogenous brain rhythms. For this reason, we hypothesized that focal delivery of theta band electrical current, using high-definition TACS, would result in improved AM performance compared to sham stimulation or transcranial direct current stimulation (TDCS). In this pilot study, 60 healthy subjects were randomized to receive high definition TACS, high definition TDCS, or sham stimulation delivered to the right fusiform cortex during encoding of visual associations. Consistent with our hypothesis, improved AM performance was observed in the TACS group, while TDCS had no effect. However, TACS also resulted in improved correct rejection of never seen items, reduced false memory, and reduced forgetting, suggesting the effect may not be specific for AM processes. Overall, this work informs strategies for improving associative memory and suggests alternating current is more effective than direct current stimulation in some contexts.

Indexed as

MemoryTheta RhythmTranscranial Direct Current StimulationAdolescentAdultFemaleHumansMaleMiddle AgedNeurodegenerative DiseasesPilot ProjectsTemporal Lobe

Identifiers

PMID31189985
PMCPMC6561937

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.