Evidence map›Paper›PMID 31189952›Full record

ArticleNature2019

Migrant memory B cells secrete luminal antibody in the vagina.

Ji Eun Oh, Norifumi Iijima, Eric Song, Peiwen Lu, Jonathan Klein, Ruoyi Jiang, Steven H Kleinstein, Akiko Iwasaki

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026
    Pooled it
  2. Trial
  3. Trial
  4. B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Microorganisms · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. IgA and the gut-vagina axis.Frontiers in immunology · 2025
    Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Ji Eun OhDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Norifumi IijimaDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Eric SongDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Peiwen LuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Jonathan KleinDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Ruoyi JiangDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Steven H KleinsteinDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Akiko IwasakiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.
Yale University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Immunity to Genital Herpes Simplex-2R01AI054359 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2004 to 2019
$5.2M
Molecular and Cellular Transport in MucusR01EB000487 · NIBIB · YALE UNIVERSITY · PI IWASAKI, AKIKO, SALTZMAN, W. MARK · 2002 to 2019
$5.0M
Viral Recognition by plasmacytoid dendritic cellR01AI064705 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2006 to 2015
$3.9M
Antiviral CTL mobilization to the genital mucosaR01AI062428 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2005 to 2015
$3.9M
COMPUTATIONAL TOOLS FOR THE ANALYSIS OF HIGH-THROUGHPUT IMMUNOGLOBULIN SEQUENCING EXPERIMENTSR01AI104739 · NIAID · YALE UNIVERSITY · PI KLEINSTEIN, STEVEN H. · 2014 to 2022
$3.6M
Vaccine Design to Concentrate Protective Antibodies at the Mucosal BorderR01AI102625 · NIAID · UNIVERSITY OF MINNESOTA · PI HAASE, ASHLEY T. · 2012 to 2015
$3.1M
B cell based protection against recurrent herpesR01AI127429 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2017 to 2021
$2.1M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysiS10OD018521 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2015 to 2015
$890k
Antiviral CTL mobilization to the genital mucosaR56AI062428 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2010 to 2010
$403k
Meningeal lymphangiogenesis effect on malignancy ofglioblastoma.F30CA239444 · NCI · YALE UNIVERSITY · PI SONG, HOYEON ERIC · 2019 to 2021
$111k
NCI NIH HHS F30 CA239444NIAID NIH HHS R01 AI054359NIAID NIH HHS R01 AI062428NIAID NIH HHS R01 AI064705NIAID NIH HHS R01 AI102625NIAID NIH HHS R01 AI104739NIAID NIH HHS R01 AI127429NIAID NIH HHS R56 AI062428NIBIB NIH HHS R01 EB000487NIGMS NIH HHS T32 GM007205NIH HHS S10 OD018521
6 · The paper itself

Abstract

Antibodies secreted into mucosal barriers serve to protect the host from a variety of pathogens, and are the basis for successful vaccines

Indexed as

AnimalsAntibodiesAntibody FormationB-LymphocytesCD4-Positive T-LymphocytesCell MovementFemaleHerpes SimplexHerpesvirus 2, HumanImmunizationImmunoglobulin AImmunoglobulin GImmunologic MemoryInterferon-gammaMiceMice, Inbred C57BLAntibodiesCxcr3 protein, mouseImmunoglobulin AImmunoglobulin GInterferon-gammaReceptors, CXCR3

Identifiers

PMID31189952
PMCPMC6609483
OpenAlexW2951133747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.