ReviewHeredity2019
Highlights of Streptomyces genetics.
Review in Heredity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Unveiling the Diversity of Culturable Microbes from the Underexplored Mingyong Glacier Landscape: A Roadmap for Leveraging the Potential of Actinomycetota.Indian journal of microbiology · 2025Article
- Biogenic synthesis of titanium nanoparticles by Streptomyces rubrolavendulae for sustainable management of Icerya aegyptiaca (Douglas).Scientific reports · 2025Article
- The first whole-genome sequence of a prospective novel sponge-associatedF1000Research · 2025Article
- Antibacterial potential and chromatographic profiling of bioactive compounds from endophyticPeerJ · 2025Article
- Molecular and Biochemical Characterization of Xylanase Produced byJournal of microbiology and biotechnology · 2024Article
- An atypical two-component system, AtcR/AtcK, simultaneously regulates the biosynthesis of multiple secondary metabolites inApplied and environmental microbiology · 2024Article
- The roles of SARP family regulators involved in secondary metabolism inFrontiers in microbiology · 2024Review
- Genome description of a potentially new species of Streptomyces isolated from the Indian Sundarbans mangrove.Access microbiology · 2024Article
- Introduction to Nutrition and Cancer.Cancer treatment and research · 2024Review
- Genomes and secondary metabolomes ofFrontiers in microbiology · 2024Article
- Investigation of machine learning algorithms for taxonomic classification of marine metagenomes.Microbiology spectrum · 2023Article
- Methyl halide transferase-based gas reporters for quantification of filamentous bacteria in microdroplet emulsions.Applied and environmental microbiology · 2023Article
- Whole genome analysis ofHeliyon · 2023Article
- The Best of Both Worlds-Streptomyces coelicolor and Streptomyces venezuelae as Model Species for Studying Antibiotic Production and Bacterial Multicellular Development.Journal of bacteriology · 2023Review
- Review
- Review
- Genome Sequence of Cluster BI1 Streptomyces griseus Phage TaidaOne.Microbiology resource announcements · 2022Article
- Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity fromRSC advances · 2022Article
- Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production inAntibiotics (Basel, Switzerland) · 2022Article
- Comparative Transcriptome-Based Mining of Genes Involved in the Export of Polyether Antibiotics for Titer Improvement.Antibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixty years ago, the actinomycetes, which include members of the genus Streptomyces, with their bacterial cellular dimensions but a mycelial growth habit like fungi, were generally regarded as a possible intermediate group, and virtually nothing was known about their genetics. We now know that they are bacteria, but with many original features. Their genome is linear with a unique mode of replication, not circular like those of nearly all other bacteria. They transfer their chromosome from donor to recipient by a conjugation mechanism, but this is radically different from the E. coli paradigm. They have twice as many genes as a typical rod-shaped bacterium like Escherichia coli or Bacillus subtilis, and the genome typically carries 20 or more gene clusters encoding the biosynthesis of antibiotics and other specialised metabolites, only a small proportion of which are expressed under typical laboratory screening conditions. This means that there is a vast number of potentially valuable compounds to be discovered when these 'sleeping' genes are activated. Streptomyces genetics has revolutionised natural product chemistry by facilitating the analysis of novel biosynthetic steps and has led to the ability to engineer novel biosynthetic pathways and hence 'unnatural natural products', with potential to generate lead compounds for use in the struggle to combat the rise of antimicrobial resistance.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.