Evidence map›Paper›PMID 31189898›Full record

ArticleNature communications2019

Variation of a major facilitator superfamily gene contributes to differential cadmium accumulation between rice subspecies.

Huili Yan, Wenxiu Xu, Jianyin Xie, Yiwei Gao, Lulu Wu, Liang Sun, Lu Feng, Xu Chen, Tian Zhang, Changhua Dai and 12 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Co-Selection of Low Cadmium Accumulation and High Yield During Tomato Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Cadmium Contamination in Asian Rice (Plants (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Rice Adaptation to Abiotic Stresses Caused by Soil Inorganic Elements.International journal of molecular sciences · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Huili YanKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.ORCID http://orcid.org/0000-0002-2243-7612
Wenxiu XuKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Jianyin XieKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Yiwei GaoCollege of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, 100083, China.ORCID http://orcid.org/0000-0001-8169-9332
Lulu WuKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Liang SunKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Lu FengKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Xu ChenKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Tian ZhangKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Changhua DaiKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Ting LiKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.ORCID http://orcid.org/0000-0002-6517-0372
Xiuni LinCollege of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, 100083, China.
Zhanying ZhangKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Xueqiang WangKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Fengmei LiKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Xiaoyang ZhuKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Jinjie LiKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Zichao LiKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.ORCID http://orcid.org/0000-0002-3186-1132
Caiyan ChenKey Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Mi MaKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Hongliang ZhangKey Lab of Crop Heterosis and Utilization of Ministry of Education, Beijing Key Lab of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China. zhangl@cau.edu.cn.
Zhenyan HeKey Laboratory of Plant Resources, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China. hezhenyan@ibcas.ac.cn.

Funding

China Postdoctoral Science Foundation 2018M64152
6 · The paper itself

Abstract

Cadmium (Cd) accumulation in rice grain poses a serious threat to human health. While several transport systems have been reported, the complicity of rice Cd transport and accumulation indicates the necessity of identifying additional genes, especially those that are responsible for Cd accumulation divergence between indica and japonica rice subspecies. Here, we show that a gene, OsCd1, belonging to the major facilitator superfamily is involved in root Cd uptake and contributes to grain accumulation in rice. Natural variation in OsCd1 with a missense mutation Val449Asp is responsible for the divergence of rice grain Cd accumulation between indica and japonica. Near-isogenic line tests confirm that the indica variety carrying the japonica allele OsCd1

Indexed as

AllelesAsparagineCadmiumCell MembraneEdible GrainHumansMembrane ProteinsMutation, MissenseOryzaPhylogenyPlant BreedingPlant RootsPolymorphism, Single NucleotideSoil PollutantsValineAsparagineCadmiumMembrane ProteinsSoil PollutantsValine

Identifiers

PMID31189898
PMCPMC6561962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.