ArticleNature communications2019
Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.Endocrine journal · 2026Review
- A cellular basis for the mammalian nocturnal-diurnal switch.Science (New York, N.Y.) · 2026Article
- Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus.Communications biology · 2026Article
- The metabolic significance of peripheral tissue clocks.Communications biology · 2025Review
- Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity.iScience · 2025Article
- Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells.Frontiers in endocrinology · 2025Article
- Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.Cell reports methods · 2024Article
- Circadian Clock and Body Temperature.Advances in experimental medicine and biology · 2024Review
- An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Circadian ribosome profiling reveals a role for theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals.Nature communications · 2022Article
- Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.Nature aging · 2022Article
- Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.Scientific reports · 2021Article
- Review: Circadian clocks and rhythms in the vascular tree.Current opinion in pharmacology · 2021Review
- A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System.Biology · 2021Review
- The Expression and Function of Circadian Rhythm Genes in Hepatocellular Carcinoma.Oxidative medicine and cellular longevity · 2021Review
- Article
- Time-Restricted G-Protein Signaling Pathways via GPR176, GInternational journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Non-coding cis-regulatory elements are essential determinants of development, but their exact impacts on behavior and physiology in adults remain elusive. Cis-element-based transcriptional regulation is believed to be crucial for generating circadian rhythms in behavior and physiology. However, genetic evidence supporting this model is based on mutations in the protein-coding sequences of clock genes. Here, we report generation of mutant mice carrying a mutation only at the E'-box cis-element in the promoter region of the core clock gene Per2. The Per2 E'-box mutation abolishes sustainable molecular clock oscillations and renders circadian locomotor activity and body temperature rhythms unstable. Without the E'-box, Per2 messenger RNA and protein expression remain at mid-to-high levels. Our work delineates the Per2 E'-box as a critical nodal element for keeping sustainable cell-autonomous circadian oscillation and reveals the extent of the impact of the non-coding cis-element in daily maintenance of animal locomotor activity and body temperature rhythmicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.