Evidence map›Paper›PMID 31189776›Full record

ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2019

Prognostic Significance of Phosphorylated Fyn in Patients with Lung Adenocarcinoma after Lung Resection.

Shigeto Nishikawa, Toshi Menju, Koji Takahashi, Ryo Miyata, Makoto Sonobe, Akihiko Yoshizawa, Hiroshi Date

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shigeto NishikawaDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Toshi MenjuDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Koji TakahashiDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Ryo MiyataDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Makoto SonobeDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Akihiko YoshizawaDepartment of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Kyoro, Japan.
Hiroshi DateDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Kyoto University · JPKyoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSrc family tyrosine kinases, including Fyn, are non-receptor tyrosine kinases that drive malignancy in various kinds of cancers. Fyn has also been suggested to be an effector of epidermal growth factor receptor (EGFR) signaling, and is recognized as a potential therapeutic target. However, little is known about the clinical importance of phosphorylated Fyn (pFyn) in lung adenocarcinoma. The purpose of this study is to examine the prognostic significance of pFyn in this disease.

methodsA total of 282 lung adenocarcinoma specimens were collected from patients who underwent surgery at our institute. A tissue microarray was assembled from paraffin-embedded tumor blocks. pFyn expression was analyzed through immunostaining of the tissue microarray and each case was classified as positive or negative. The association of clinical information with pFyn expression was analyzed statistically.

resultspFyn was positive in 107 cases. A pFyn-positive status was significantly associated with male gender, p53 mutant, pathological stage, tumor size, plural invasion, lymphatic invasion, vascular invasion, and differentiation. pFyn positivity was associated with poor relapse-free survival (RFS; hazard ratio [HR]: 2.11, 95% confidence interval [CI]: 1.32-3.42, p <0.01) and poor overall survival (OS; HR: 1.95, 95% CI: 1.17-3.33, p = 0.01).

conclusionpFyn expression may affect the prognosis of patients with lung adenocarcinoma after lung resection.

Indexed as

PneumonectomyAdenocarcinoma of LungAgedBiomarkers, TumorFemaleHumansImmunohistochemistryLung NeoplasmsMaleMutationPhosphorylationProgression-Free SurvivalProto-Oncogene Proteins c-fynRetrospective StudiesRisk FactorsTime FactorsBiomarkers, TumorFYN protein, humanProto-Oncogene Proteins c-fynTP53 protein, humanTumor Suppressor Protein p53immunohistochemistrylung adenocarcinomaphosphorylated Fynsurvival analysis

Identifiers

PMID31189776
PMCPMC6823168
OpenAlexW2952707708

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.