Evidence map›Paper›PMID 31189704›Full record

ArticleJournal of virology2019

Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.

Xing Liu, Rachel Matrenec, Michaela U Gack, Bin He

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Autophagy in the normal and diseased cornea.Experimental eye research · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xing LiuDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Rachel MatrenecDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Michaela U GackDepartment of Microbiology, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-2163-2598
Bin HeDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA tshuo@uic.edu.
University of Illinois Urbana-Champaign · USUniversity of Chicago · US

Funding

Regulation of Host Innate Immunity Against Viral InfectionR01AI087846 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2010 to 2020
$3.9M
Regulation of Host Innate Immunity Against Viral InfectionR37AI087846 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Michaela Ulrike Gack · 2021 to 2026
$2.8M
Viral determinants in HSV virulenceR01AI148148 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HE, BIN · 2020 to 2024
$2.4M
Attenuated HSV for Vaccine DevelopmentR21AI119618 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HE, BIN · 2016 to 2017
$440k
NIAID NIH HHS R01 AI087846NIAID NIH HHS R01 AI148148NIAID NIH HHS R21 AI119618NIAID NIH HHS R37 AI087846
6 · The paper itself

Abstract

The Us11 protein encoded by herpes simplex virus 1 (HSV-1) functions to impair autophagy; however, the molecular mechanisms of this inhibition remain to be fully established. Here, we report that the Us11 protein targets

Indexed as

AnimalsAutophagyBinding SitesCells, CulturedChlorocebus aethiopsDown-RegulationGTP-Binding ProteinsHEK293 CellsHerpesvirus 1, HumanHumansProtein DomainsProtein Serine-Threonine KinasesRNA-Binding ProteinsVero CellsViral ProteinsVirus ReplicationGTP-Binding ProteinsProtein Serine-Threonine KinasesRNA-Binding ProteinsTBK1 protein, humanTRIM23 protein, humanUS11 protein, herpesvirusViral Proteinsautophagyherpes simplex virusviral replicationvirus-host interactions

Identifiers

PMID31189704
PMCPMC6694819
OpenAlexW2950749755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.