ReviewCanadian family physician Medecin de famille canadien2019
Normal-weight central obesity: Unique hazard of the toxic waist.
Review in Canadian family physician Medecin de famille canadien, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- High body mass index within the normal weight range and risk of type 2 diabetes and hypertension in US and Europe: a systematic review and meta-analysis.International journal of obesity (2005) · 2026Pooled it
- Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses.Frontiers in endocrinology · 2024Pooled it
- Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies.BMJ (Clinical research ed.) · 2020Pooled it
- Hidden cardiometabolic risk: normal weight central obesity in a nationally representative study from Türkiye.BMC public health · 2026Article
- Ten-year cardiometabolic progression and health-related quality of life in individuals with isolated abdominal obesity.BMC public health · 2026Article
- Long-term trends in central obesity in England: an age-period-cohort approach.International journal of obesity (2005) · 2026Article
- Associations of actigraphic sleep parameters with adipokines in older adults in the Baltimore longitudinal study of aging.Sleep advances : a journal of the Sleep Research Society · 2026Article
- The continuum of prevention and heart failure in cardiovascular medicine: A joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology.American journal of preventive cardiology · 2025Review
- Chronicity of obesity and the importance of early treatment to reduce cardiometabolic risk and improve body composition.Obesity pillars · 2025Review
- Age-Related Trends in Dual-Energy X-Ray Absorptiometry-Measured Adiposity and Their Clinical Relevance: A Multicenter Cross-Sectional Study of Korean Peri- and Postmenopausal Women.Medicina (Kaunas, Lithuania) · 2025Article
- The Association Between Waist Circumference and the Risk of Osteoporosis in Non-overweight US Adults.Indian journal of orthopaedics · 2025Article
- Evaluating Abdominal Obesity by Waist Circumference, Anthropometric Indices and Bioelectrical Impedance Analysis: A Comparative Pilot Study.Obesity science & practice · 2025Article
- Patterns of general and abdominal obesity and their association with hypertension control in the iranian hypertensive population: insights from a nationwide study.BMC public health · 2025Article
- Influence of Sex and Body Composition on Aerobic Capacity in Normal Weight Lean, Normal Weight Obese, and Obese Phenotypes.International journal of environmental research and public health · 2025Article
- Smoking, Obesity, and Post-Cessation Weight Gain: Neurobiological Intersection and Treatment Recommendations.Journal of multidisciplinary healthcare · 2025Review
- The Relationship Between Perimesenteric Fat and Measures of Central Adiposity in Young Adults.Cureus · 2024Article
- Prevalence and Influencing Factors of Central Obesity among Adults in China: China Nutrition and Health Surveillance (2015-2017).Nutrients · 2024Article
- Waist-to-height ratio and body fat percentage as risk factors for ischemic cardiovascular disease: a prospective cohort study from UK Biobank.The American journal of clinical nutrition · 2024Article
- Higher childhood weight gain, lower skeletal muscle mass, and higher cereal consumption in normal-weight Japanese women with high-percentage trunk fat: a subanalysis study.Diabetology international · 2024Article
- Association between anthropometric indices and 5-year hypertension incidence in the general Japanese population.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
Corrections and comments
- Commented on by
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the mortality risk presented by normal-weight central obesity, to identify a clinical measure to aid in the identification of this phenotype, and to explore the means for mitigation of this risk. QUALITY OF EVIDENCE: Only prospective cohort studies (level II) comparing participants with central obesity at normal weight with those at higher levels of body mass index (BMI) were found. Good level I studies were available to demonstrate the effect of diet and exercise interventions on central obesity and mortality. MAIN MESSAGE: Participants with atherogenic dyslipidemia who are centrally obese at normal BMI are at similar, and possibly higher, mortality risk compared with those who are centrally obese and overweight or obese according to their BMI. Waist-to-height ratio might be the most pragmatic clinical measure of central obesity. The Mediterranean diet is an effective intervention to prevent ongoing weight gain while reducing abdominal girth. Low levels of exercise can also reduce waist circumference. Weight loss need not be an objective.
conclusionA waist-to-height ratio exceeding 0.5 at normal BMI identifies elevated mortality risk for cardiometabolic disease. This risk might equal or exceed that of centrally obese patients who are overweight or obese. Modest dietary and exercise interventions can be effective in mitigation of this risk.
Indexed as
Identifiers
31189627PMC6738397W2952752490What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.