Evidence map›Paper›PMID 31189586›Full record

ArticleJournal of clinical microbiology2019

Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic Performance in Settings Where Chagas Disease and American Cutaneous or Visceral Leishmaniasis Are Coendemic.

Ramona Tavares Daltro, Leonardo Maia Leony, Natália Erdens Maron Freitas, Ângelo Antônio Oliveira Silva, Emily Ferreira Santos, Rodrigo Pimenta Del-Rei, Maria Edileuza Felinto Brito, Sinval Pinto Brandão-Filho, Yara Miranda Gomes, Marcelo Sousa Silva and 8 more

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Double-antigen sandwich ELISA based on chimeric antigens for detection of antibodies to Trypanosoma cruzi in human sera - A phase II study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Article
  4. Frontiers in microbiology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Performance of Extracellular Vesicles FromJournal of parasitology research · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Chagas Disease: A Silent Threat for Dogs and Humans.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Characterization of NovelInternational journal of molecular sciences · 2024
    Article
  18. Article
  19. Assessment of Cross-Reactivity of ChimericDiagnostics (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Ramona Tavares DaltroGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Leonardo Maia LeonyGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Natália Erdens Maron FreitasGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Ângelo Antônio Oliveira SilvaGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Emily Ferreira SantosGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Rodrigo Pimenta Del-ReiFaculty of Technology and Sciences of Bahia, Salvador, Bahia, Brazil.
Maria Edileuza Felinto BritoAggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil.
Sinval Pinto Brandão-FilhoAggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil.
Yara Miranda GomesAggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil.
Marcelo Sousa SilvaFederal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Silvia Tavares DonatoFederal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Selma Maria Bezerra JeronimoFederal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Gloria Regina de Góis MonteiroFederal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Lucas Pedreira CarvalhoGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Andréa Santos MagalhãesFederal University of Bahia, Salvador, Bahia, Brazil.
Nilson Ivo Tonin ZanchinCarlos Chagas Institute, Oswaldo Cruz Foundation, Curitiba, Paraná, Brazil.
Paola Alejandra Fiorani CeledonMolecular Biology Institute of Paraná, Curitiba, Paraná, Brazil.
Fred Luciano Neves SantosGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil fred.santos@bahia.fiocruz.br.ORCID 0000-0002-3944-0818
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio Grande do Norte · BRUniversidade Federal da Bahia · BRFundação Carlos Chagas · BRInstituto de Biologia Molecular do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric

Indexed as

Cross ReactionsAntibodies, ProtozoanAntigens, ProtozoanChagas DiseaseEndemic DiseasesEnzyme-Linked Immunosorbent AssayHumansLatent Class AnalysisLeishmaniasis, CutaneousLeishmaniasis, VisceralRecombinant Fusion ProteinsSensitivity and SpecificityTrypanosoma cruziAntibodies, ProtozoanAntigens, ProtozoanRecombinant Fusion ProteinsAmerican cutaneous leishmaniasisChagas diseasecross-reactivityrecombinant chimeric antigensvisceral leishmaniasis

Identifiers

PMID31189586
PMCPMC6663885
OpenAlexW2951014745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.