ArticleJournal of clinical microbiology2019
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Evaluation of genotype characteristics and drug resistance mutations in patients with chronic hepatitis B.Scientific reports · 2024Article
- The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection.Journal of virus eradication · 2023Article
- Despite low viral titer in saliva samples, Sanger-based SARS-CoV-2 spike gene sequencing is highly applicable for the variant identification.BMC medical genomics · 2023Article
- Using machine learning models to predict HBeAg seroconversion in CHB patients receiving pegylated interferon-α monotherapy.Journal of clinical laboratory analysis · 2022Article
- Precision therapy for three Chinese families with maturity-onset diabetes of the young (MODY12).Frontiers in endocrinology · 2022Article
- Detection of S-HBsAg Mutations in Patients with Hematologic Malignancies.Diagnostics (Basel, Switzerland) · 2021Article
- Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.Emerging microbes & infections · 2020Article
- Article
- Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.Infection and drug resistance · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in hepatitis B virus (HBV) reverse transcriptase (RT) are associated with nucleos(t)ide analogue (NA) resistance during long-term antiviral treatment. However, the characterization of mutations in HBV RT in untreated patients has not yet been well illustrated. The objective of this study was to investigate the characterization and clinical significance of natural variability in HBV RT in treatment-naive patients. HBV RT sequences were analyzed in 427 patients by Sanger sequencing and in 66 patients by next-generation sequencing. Primary or secondary NA resistance (NA
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