ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Amblyopia Affects the ON Visual Pathway More than the OFF.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Rethinking perceptual distortions in amblyopia: toward a multi-feature, visual-field-wide perspective.Frontiers in neuroscience · 2026Article
- Phantom Forms in Amblyopic Vision and what they reveal about the Generative Brain.bioRxiv : the preprint server for biology · 2025Article
- Visual Distortions in Human Amblyopia Are Correlated with Deficits in Contrast Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
- Article
- Interocular suppression in chromoluminance patterns measured with SSVEP.Journal of vision · 2025Article
- Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes.Investigative ophthalmology & visual science · 2025Article
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Visual Field Asymmetries in Responses to ON and OFF Pathway Biasing Stimuli.Visual neuroscience · 2024Article
- Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children.iScience · 2024Article
- Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Measuring the Interocular Delay and its Link to Visual Acuity in Amblyopia.Investigative ophthalmology & visual science · 2024Article
- Understanding contrast perception in amblyopia: a psychophysical analysis of the ON and OFF visual pathways.Frontiers in psychology · 2024Article
- Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis.Investigative ophthalmology & visual science · 2023Article
- Differences in visual stimulation between reading and walking and implications for myopia development.Journal of vision · 2023Article
- Luminance Contrast Shifts Dominance Balance between ON and OFF Pathways in Human Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Automatic compensation enhances the orientation perception in chronic astigmatism.Scientific reports · 2022Article
- Article
- Induced astigmatism biases the orientation information represented in multivariate electroencephalogram activities.Human brain mapping · 2021Article
- Motion-Based Acuity Task: Full Visual Field Measurement of Shape and Motion Perception.Translational vision science & technology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Visual information reaches the cerebral cortex through parallel ON and OFF pathways that signal the presence of light and dark stimuli in visual scenes. We have previously demonstrated that optical blur reduces visual salience more for light than dark stimuli because it removes the high spatial frequencies from the stimulus, and low spatial frequencies drive weaker ON than OFF cortical responses. Therefore, we hypothesized that sustained optical blur during brain development should weaken ON cortical pathways more than OFF, increasing the dominance of darks in visual perception. Here we provide support for this hypothesis in humans with anisometropic amblyopia who suffered sustained optical blur early after birth in one of the eyes. In addition, we show that the dark dominance in visual perception also increases in strabismic amblyopes that have their vision to high spatial frequencies reduced by mechanisms not associated with optical blur. Together, we show that amblyopia increases visual dark dominance by 3-10 times and that the increase in dark dominance is strongly correlated with amblyopia severity. These results can be replicated with a computational model that uses greater luminance/response saturation in ON than OFF pathways and, as a consequence, reduces more ON than OFF cortical responses to stimuli with low spatial frequencies. We conclude that amblyopia affects the ON cortical pathway more than the OFF, a finding that could have implications for future amblyopia treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.