ArticleJournal of immunology (Baltimore, Md. : 1950)2019
Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity.
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- The transcription factor ZNF683 marks an exhaustion-like GZMBFrontiers in immunology · 2026Article
- Immunodynamic Disruption in Sepsis: Mechanisms and Strategies for Personalized Immunomodulation.Biomedicines · 2025Review
- Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- Diagnostic and prognostic significance of apelin-13, APJ for sepsis in the emergency department: A prospective study.Heliyon · 2024Article
- Defining Parameters That Modulate Susceptibility and Protection to Respiratory Murine Coronavirus MHV1 Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells.PLoS pathogens · 2023Article
- The Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Relationship Between the Expression of PD-1 and CTLA-4 on T Lymphocytes and the Severity and Prognosis of Sepsis.International journal of general medicine · 2023Article
- Natural killer cells in sepsis: Friends or foes?Frontiers in immunology · 2023Review
- Autoimmunity Increases Susceptibility to and Mortality from Sepsis.ImmunoHorizons · 2021Article
- Article
- Severity of Sepsis Determines the Degree of Impairment Observed in Circulatory and Tissue-Resident Memory CD8 T Cell Populations.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Prolonged Reactive Oxygen Species Production following Septic Insult.ImmunoHorizons · 2021Observational
- Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Ectopic Tcf1 expression instills a stem-like program in exhausted CD8Cellular & molecular immunology · 2021Article
- Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis.Communications biology · 2021Article
- NK Cell-Derived IL-10 Supports Host Survival during Sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients.Journal of immunology (Baltimore, Md. : 1950) · 2021Observational
- Club Cell Protein 16 Attenuates CD16Journal of immunology research · 2021Article
- Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells.eLife · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Patients who survive sepsis experience long-term immunoparalysis characterized by numerical and/or functional lesions in innate and adaptive immunity that increase the host's susceptibility to secondary complications. The extent to which tumor development/growth is affected in sepsis survivors remains unknown. In this study, we show cecal ligation and puncture (CLP) surgery renders mice permissive to increased B16 melanoma growth weeks/months after sepsis induction. CD8 T cells provide partial protection in this model, and tumors from sepsis survivors had a reduced frequency of CD8 tumor-infiltrating lymphocytes (TILs) concomitant with an increased tumor burden. Interestingly, the postseptic environment reduced the number of CD8 TILs with high expression of activating/inhibitory receptors PD-1 and LAG-3 (denoted PD-1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.