ArticleCancer discovery2019
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.
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Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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116citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
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Who cites it
116 citing papers in PubMed, 165 citations in OpenAlex.
- Pathological response and metabolites' prognostic role in HER2-positive breast cancer treated with neoadjuvant pyrotinib, trastuzumab, nab-paclitaxel, and carboplatin: a single-arm phase II trial.Breast cancer research : BCR · 2025Trial
- Exploiting an epigenetic resistance mechanism to PI3-kinase inhibition in leukemic stem cells.Leukemia · 2026Article
- Metabolic reprogramming drives pancreatic β cell neogenesis from α cells.Nature chemical biology · 2026Article
- Distinct metabolic dependency on BCAA defines cancer stemness and malignancy in human triple-negative breast cancer.Cell reports · 2026Article
- Suppression of UCP2 alleviates leukemogenesis by enhancing branched-chain amino acids-induced oxidative stress via activating the PI3K/AKT/mTOR signaling pathway.Genes & diseases · 2026Article
- Mevalonate pathway rewiring driven by enhancer remodelling confers resistance to KRAS inhibitors in colorectal cancer.Nature communications · 2026Article
- Myeloid Malignancies Beyond the Cell: Targeting the Tumour Microenvironment with Next-Generation Immunotherapies.Cancers · 2026Review
- A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- BCAA catabolism mediates POU2AF1 propionylation to enhance T-ALL development.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Distal enhancer RNAs regulate alternative promoter usage of MYB and drug resistance in human leukemia cells.Leukemia · 2026Article
- The BCAA metabolism-related gene BCAT1 promotes the progression of bladder urothelial carcinoma through the PI3K/AKT/mTOR signalling pathway.Functional & integrative genomics · 2026Article
- Branched-chain amino acid transaminases as promising targets in tumor therapy.Frontiers in cell and developmental biology · 2026Review
- BCAAs and related metabolic enzymes: partners in crime driving tumor development.Frontiers in cell and developmental biology · 2026Review
- Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche.The Journal of clinical investigation · 2025Article
- DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance.Nature communications · 2025Article
- Histone modifications in the regulation of erythropoiesis.Annals of medicine · 2025Review
- Astatine-211-Labeled Therapy Targeting Amino Acid Transporters: Overcoming Drug Resistance in Non-Small Cell Lung Cancer.International journal of molecular sciences · 2025Review
- α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development.Blood · 2025Article
- Review
- Revealing the landscape of targeting mitochondrial functions and behaviors to overcome cancer chemoresistance.Journal of the National Cancer Center · 2025Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 2 countries.
Zhimin Gu *Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Yuxuan Liu *Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Feng CaiChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
McKenzie PatrickChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Jakub ZmajkovicDepartment of Biomedicine, University Hospital Basel, Basel, Switzerland.
Hui CaoChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Yuannyu ZhangChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Alpaslan TasdoganChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Mingyi ChenDepartment of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Le QiChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Xin LiuChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Kailong LiChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Junhua LyuChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Kathryn E DickersonChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0003-1220-2243
Weina ChenDepartment of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Min NiChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Miami, Florida.ORCID 0000-0003-4617-9651
Sean J MorrisonChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Radek C SkodaDepartment of Biomedicine, University Hospital Basel, Basel, Switzerland.
Ralph J DeBerardinisChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas.
Jian XuChildren's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, Texas. jian.xu@utsouthwestern.edu.ORCID 0000-0003-1988-7337
Southwestern Medical Center · USThe University of Texas Southwestern Medical Center · USHoward Hughes Medical Institute · USUniversity Hospital of Basel · CHUniversity of Miami · US
Funding
Metabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MMolecular Analysis of Transcriptional Enhancers in HematopoiesisR01DK111430 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jian Xu · 2016 to 2026
$4.8MANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASEK12HD068369 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X · 2011 to 2020
$3.0MTargeting Metabolic Liabilities of Leukemia-Initiating Cells (R01CA230631)R01CA230631 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XU, JIAN · 2019 to 2023
$1.8MHoward Hughes Medical InstituteNCI NIH HHS R01 CA230631NCI NIH HHS R35 CA220449NICHD NIH HHS K12 HD068369NIDDK NIH HHS R01 DK111430
Abstract
Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here, we show that EZH2 and NRAS
Indexed as
Amino Acids, Branched-ChainAnimalsEnhancer of Zeste Homolog 2 ProteinGTP PhosphohydrolasesHumansLeukemiaMembrane ProteinsMiceMutationMyeloproliferative DisordersNeoplasm TransplantationSignal TransductionTOR Serine-Threonine KinasesTransaminasesAmino Acids, Branched-ChainBCAT1 protein, humanEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanGTP PhosphohydrolasesMembrane ProteinsMTOR protein, humanNRAS protein, humanTOR Serine-Threonine KinasesTransaminases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.