ArticleBMC genomics2019
Evolution and comparative genomics of the most common Trichoderma species.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it, 276 citations in OpenAlex.
- BioprospectingFrontiers in fungal biology · 2021Pooled it
- Phylogenomic and Comparative Genomic Analyses Reveal Deep Evolutionary Structure and Cryptic Diversity in the GenusInternational journal of molecular sciences · 2026Article
- Isolation, Biocontrol Efficacy and Genomic Analysis ofMicroorganisms · 2026Article
- NOD-Like Receptor Genes Undergo Diversity-Enhancing Evolution in a Fungal Species Complex.Genome biology and evolution · 2026Article
- Comparing the Effect of Biochar and Poultry Manure on the Metabolomic Profile of Tomatoes (Metabolites · 2026Article
- Mechanisms of Trichoderma-Mediated Plant Growth Promotion: From Metabolites to Plant Responses.Plants (Basel, Switzerland) · 2026Review
- Article
- Seed-Associated Trichoderma and Their Potential as Biocontrol Agents Against Plant Diseases.Environmental microbiology · 2026Article
- Evidence for Cryptic Sex in Escovopsis, a Mycoparasite in the Fungus-Growing Ant Symbiosis.Genome biology and evolution · 2026Article
- Fertilization time and oocyte spindle integrity: implication for embryo ploidy.Reproduction & fertility · 2026Article
- Multilocus Identification of IndigenousCurrent issues in molecular biology · 2026Article
- Article
- Unveiling the carbohydrate-active enzyme repertoire of Trichoderma caribbaeum IHBT through whole-genome analysis and transcriptional profiling.Archives of microbiology · 2026Article
- TrichoBase: a standardized genomic resource for comparative genomics of Trichoderma species.BMC genomic data · 2026Article
- Purification-free antifungal biocontrol platform using engineered Saccharomyces cerevisiae secreting Trichoderma atroviride chitinase.Bioresources and bioprocessing · 2026Article
- Impact of DNA Extraction Strategies on Genomic and Bioinformatic Outcomes in Eight Selected Fungal Strains.Journal of fungi (Basel, Switzerland) · 2026Article
- Dual Biocontrol and Plant Growth-Promoting Effects ofJournal of fungi (Basel, Switzerland) · 2026Article
- Vegetal residue-based formulation of Trichoderma ossianense, a new indigenous vineyard species adapted to alkaline pH with potential biocontrol ability against Black-foot disease pathogens.Pest management science · 2026Article
- Article
- Phenogenomics reveals the ecology and evolution of Trichoderma fungi for sustainable agriculture.Nature microbiology · 2026Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 9 countries.
Funding
Abstract
backgroundThe growing importance of the ubiquitous fungal genus Trichoderma (Hypocreales, Ascomycota) requires understanding of its biology and evolution. Many Trichoderma species are used as biofertilizers and biofungicides and T. reesei is the model organism for industrial production of cellulolytic enzymes. In addition, some highly opportunistic species devastate mushroom farms and can become pathogens of humans. A comparative analysis of the first three whole genomes revealed mycoparasitism as the innate feature of Trichoderma. However, the evolution of these traits is not yet understood.
resultsWe selected 12 most commonly occurring Trichoderma species and studied the evolution of their genome sequences. Trichoderma evolved in the time of the Cretaceous-Palaeogene extinction event 66 (±15) mya, but the formation of extant sections (Longibrachiatum, Trichoderma) or clades (Harzianum/Virens) happened in Oligocene. The evolution of the Harzianum clade and section Trichoderma was accompanied by significant gene gain, but the ancestor of section Longibrachiatum experienced rapid gene loss. The highest number of genes gained encoded ankyrins, HET domain proteins and transcription factors. We also identified the Trichoderma core genome, completely curated its annotation, investigated several gene families in detail and compared the results to those of other fungi. Eighty percent of those genes for which a function could be predicted were also found in other fungi, but only 67% of those without a predictable function.
conclusionsOur study presents a time scaled pattern of genome evolution in 12 Trichoderma species from three phylogenetically distant clades/sections and a comprehensive analysis of their genes. The data offer insights in the evolution of a mycoparasite towards a generalist.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.