Evidence map›Paper›PMID 31189369›Full record

ArticleJournal of dental research2019

Macrophages Promote Growth of Squamous Cancer Independent of T cells.

F L Wu, K Nolan, A A Strait, L Bian, K A Nguyen, J H Wang, A Jimeno, H M Zhou, C D Young, X J Wang

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

F L Wu1 State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
K Nolan2 Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
A A Strait2 Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
L Bian2 Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
K A Nguyen2 Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
J H Wang3 Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
A Jimeno4 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
H M Zhou1 State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
C D Young2 Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
X J Wang2 Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus · USSichuan University · CNVA Eastern Colorado Health Care System · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
Targeting PD-L1 interactome signaling to enhance immunotherapy efficacy in head and neck squamous cell cancerR01CA149456 · NCI · UNIVERSITY OF COLORADO DENVER · PI Antonio Jimeno · 2010 to 2026
$5.6M
Elucidating Mechanism of Immune Evasion in Head and Neck CancersR01DE027329 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JING HONG, WANG, XIAO-JING · 2018 to 2022
$2.8M
Mechanisms of Dual Inhibition of TGFbeta/PD-L1 in HNSCCR01DE028420 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI WANG, JING HONG, WANG, XIAO-JING · 2019 to 2023
$2.7M
Identifying oral cancer stem cell properties affected by the microenvironmentR01DE024371 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI JIMENO, ANTONIO, WANG, XIAO-JING · 2014 to 2017
$2.1M
Mechanisms of Breaking Indolence in Squamous Cell CarcinomaI01BX003232 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI WANG, XIAO-JING · 2017 to 2025
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BLRD VA I01 BX003232NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA149456NIDCR NIH HHS R01 DE024371NIDCR NIH HHS R01 DE027329NIDCR NIH HHS R01 DE028420NIGMS NIH HHS T32 GM007635
6 · The paper itself

Abstract

Oral cancers, primarily squamous cell carcinomas (SCCs), progress either slowly or aggressively. Here we assessed the role of macrophages in SCC behavior. We used mouse SCC cells derived from tumors harboring a Kras

Indexed as

AnimalsCarcinoma, Squamous CellCell Line, TumorClodronic AcidFemaleHumansMacrophagesMiceMice, Inbred C57BLMice, NudeT-LymphocytesClodronic Acidangiogenesisapoptosisclodronic acidimmunitymetastasissquamous cell carcinoma

Identifiers

PMID31189369
PMCPMC6616122
OpenAlexW2950541277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.