Evidence map›Paper›PMID 31188937›Full record

ArticleGenetics and molecular biology

Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission.

Luisa Zupin, Vania Polesello, Anselmo Jiro Kamada, Rossella Gratton, Ludovica Segat, Louise Kuhn, Sergio Crovella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Luisa ZupinDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0001-5886-9129
Vania PoleselloInstitute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy.
Anselmo Jiro KamadaDepartmento de Genética, Universide Federal de Pernambuco, Recife, PE, Brazil.
Rossella GrattonInstitute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy.
Ludovica SegatInstitute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy.
Louise KuhnGertrude H. Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Sergio CrovellaDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
IRCCS Materno Infantile Burlo Garofolo · ITColumbia University · USUniversidade Federal de Pernambuco · BRUniversity of Trieste · IT

Funding

Short Exclusive Breastfeeding to Reduce Postnatal Transmission of HIVR01HD039611 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI THEA, DONALD M · 2000 to 2006
$8.0M
Pathogenesis of Mother to Child Transmission of HIVR01HD040777 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALDROVANDI, GRACE M · 2002 to 2011
$4.4M
Safer Weaning Practices for HIV-infected womenR01HD057617 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2007 to 2011
$2.0M
NICHD NIH HHS R01 HD039611NICHD NIH HHS R01 HD040777NICHD NIH HHS R01 HD057617
6 · The paper itself

Abstract

Perforin-1, a component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of the c.900C > T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C > T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C > T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C > T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.

Identifiers

PMID31188937
PMCPMC6905447
OpenAlexW2952544650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.