ArticlePloS one2019
Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Effects of fermentable fiber and polyphenol supplementation on mood and cognition in adults during hypobaric hypoxia exposure.Physiological reports · 2025Trial
- Simulated Acute Hypobaric Hypoxia Effects on Cognition in Helicopter Emergency Medical Service Personnel - A Randomized, Controlled, Single-Blind, Crossover Trial.Human factors · 2024Trial
- Physiological Adaptation Buffers Personality-Linked Psychopathology Under High-Altitude Hypoxia.Brain and behavior · 2026Article
- Sleep quality among military personnel exposed to high altitude: a cross-sectional study of oxygen supplementation and altitude transition.Frontiers in public health · 2026Article
- Modulation of cerebral blood flow and cognition by hyperthermia and hypoxia: An electroencephalographic event-related potentials perspective.Experimental physiology · 2025Review
- The Effects of Nocturnal Hypoxemia on Cognitive Performance in Andean Highlanders.High altitude medicine & biology · 2025Article
- Effect of altitude on the spatiotemporal signal characteristics of inversion face recognition.Scientific reports · 2025Article
- Stroke in High-Altitude Areas.Brain and behavior · 2025Review
- Change in sleep, gastrointestinal symptoms, and mood states at high altitude (4500m) for 6 months.Sleep & breathing = Schlaf & Atmung · 2025Article
- Affective and fatigue responses to incremental exercise: the effect of hypoxic and normoxic training protocols.Frontiers in sports and active living · 2025Article
- Dynamic brain functional states associated with inhibition control under different altitudes.Cognitive neurodynamics · 2024Article
- Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure.Pflugers Archiv : European journal of physiology · 2024Article
- Influence of short-term hypoxic exposure on spatial learning and memory function and brain-derived neurotrophic factor in rats-A practical implication to human's lost way.Frontiers in behavioral neuroscience · 2024Article
- Hypoxic preacclimatization combining intermittent hypoxia exposure with physical exercise significantly promotes the tolerance to acute hypoxia.Frontiers in physiology · 2024Article
- Added Inspiratory Resistance Does Not Impair Cognitive Function and Mood State.International journal of environmental research and public health · 2023Article
- A bibliometric analysis of the studies in high-altitude induced sleep disturbances and cognitive impairment research.Frontiers in physiology · 2023Article
- Positive Psychological Changes at High Altitude Shown by the Low Landers after the Yoga Intervention-Sudarshan Kriya Yoga (SKY).Annals of neurosciences · 2023Article
- Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure.Frontiers in physiology · 2023Review
- Effects of acute high-altitude exposure on working memory: A functional near-infrared spectroscopy study.Brain and behavior · 2022Article
- The Pathogenesis of Central and Complex Sleep Apnea.Current neurology and neuroscience reports · 2022Review
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their independent contributions at high altitude remain unknown. Adaptive servoventilation (ASV) improves sleep quality by stabilizing breathing and preventing central apneas without supplemental oxygen. We compared the efficacy of ASV and supplemental oxygen sleep treatments for improving daytime cognitive function and mood in high-altitude visitors (N = 18) during acclimatization to 3,800 m. Each night, subjects were randomly provided with ASV, supplemental oxygen (SpO2 > 95%), or no treatment. Each morning subjects completed a series of cognitive function tests and questionnaires to assess mood and multiple aspects of cognitive performance. We found that both ASV and supplemental oxygen (O2) improved daytime feelings of confusion (ASV: p < 0.01; O2: p < 0.05) and fatigue (ASV: p < 0.01; O2: p < 0.01) but did not improve other measures of cognitive performance at high altitude. However, performance improved on the trail making tests (TMT) A and B (p < 0.001), the balloon analog risk test (p < 0.0001), and the psychomotor vigilance test (p < 0.01) over the course of three days at altitude after controlling for effects of sleep treatments. Compared to sea level, subjects reported higher levels of confusion (p < 0.01) and performed worse on the TMT A (p < 0.05) and the emotion recognition test (p < 0.05) on nights when they received no treatment at high altitude. These results suggest that stabilizing breathing (ASV) or increasing oxygenation (supplemental oxygen) during sleep can reduce feelings of fatigue and confusion, but that daytime hypoxia may play a larger role in other cognitive impairments reported at high altitude. Furthermore, this study provides evidence that some aspects of cognition (executive control, risk inhibition, sustained attention) improve with acclimatization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.