Evidence map›Paper›PMID 31188739›Full record

ArticleMolecular biology of the cell2019

The

Lathiena A Manning, Kia Z Perez-Vale, Kristina N Schaefer, Mycah T Sewell, Mark Peifer

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lathiena A ManningDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Kia Z Perez-ValeCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Kristina N SchaeferCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Mycah T SewellDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Mark PeiferDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
University of North Carolina at Chapel Hill · US

Funding

SEEDING POSTDOCTORAL INNOVATORS IN RESEARCH &EDUCATIONK12GM000678 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DONALD T LYSLE, Kathryn Joanna Reissner · 1999 to 2026
$30.9M
UNC Initiative for Maximizing Student DevelopmentR25GM055336 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COOK, JEANETTE GOWEN, KASH, THOMAS L. · 1996 to 2023
$12.1M
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
UNC PREP in the Biomedical Sciences - Administrative SupplementR25GM089569 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBINSON, DONITA L, RODRIGUEZ-ROMAGUERA, JOSE · 2010 to 2024
$5.6M
Defining the molecular mechanisms underlying apical-basal polarity establishment and morphogenesisF31GM131521 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEREZ-VALE, KIA ZOLEE · 2019 to 2020
$71k
NIGMS NIH HHS F31 GM131521NIGMS NIH HHS K12 GM000678NIGMS NIH HHS R25 GM055336NIGMS NIH HHS R25 GM089569NIGMS NIH HHS R35 GM118096NIGMS NIH HHS T32 GM007092NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

During morphogenesis, cells must change shape and move without disrupting tissue integrity. This requires cell-cell junctions to allow dynamic remodeling while resisting forces generated by the actomyosin cytoskeleton. Multiple proteins play roles in junctional-cytoskeletal linkage, but the mechanisms by which they act remain unclear.

Indexed as

Adherens JunctionsAnimalsCell ShapeCytoskeletonDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentEpidermisEpithelial CellsHomeostasisIntracellular Signaling Peptides and ProteinsMorphogenesisMutationPhenotypePseudopodiaTight Junction Proteinsbaz protein, Drosophilacno protein, DrosophilaDrosophila ProteinsIntracellular Signaling Peptides and Proteinspyd protein, DrosophilaTight Junction Proteins

Identifiers

PMID31188739
PMCPMC6727765
OpenAlexW2952815963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.