Evidence map›Paper›PMID 31188489›Full record

ArticleJournal of cellular physiology2020

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice.

Jungeun Yu, Christian W Siebel, Lauren Schilling, Ernesto Canalis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Relevance of Notch Signaling for Bone Metabolism and Regeneration.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Review
  12. Article
  13. Antisense oligonucleotides targetingThe Journal of biological chemistry · 2020
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jungeun YuDepartment of Orthopaedic Surgery, UConn Health, Farmington, Connecticut.
Christian W SiebelDepartment of Discovery Oncology, Genentech, Inc, South San Francisco, California.
Lauren SchillingThe UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut.
Ernesto CanalisDepartment of Orthopaedic Surgery, UConn Health, Farmington, Connecticut.ORCID 0000-0002-9154-952X
UConn Health · USDiscovery Centre · CA

Funding

The Skeleton of Lateral Meningocele SyndromeR01AR072987 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2018 to 2023
$2.2M
Role of Notch Signaling in OsteocytesR01AR063049 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CANALIS, ERNESTO · 2013 to 2017
$1.8M
NIAMS NIH HHS R01 AR063049NIAMS NIH HHS R01 AR072987
6 · The paper itself

Abstract

Lateral meningocele syndrome (LMS), a genetic disorder characterized by meningoceles and skeletal abnormalities, is associated with NOTCH3 mutations. We created a mouse model of LMS (Notch3

Indexed as

Abnormalities, MultipleAnimalsAntibodiesBone and BonesFemaleGenetic Predisposition to DiseaseMacrophagesMaleMeningoceleMiceMutationOsteoblastsReceptor, Notch3X-Ray MicrotomographyAntibodiesNotch3 protein, mouseReceptor, Notch3bone remodelinggenetic disorderslateral meningocele syndromeNotchNotch antibodies

Identifiers

PMID31188489
PMCPMC6778702
OpenAlexW2950103267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.