Evidence map›Paper›PMID 31188483›Full record

SynthesisClinical cardiology2019

Balloon pulmonary angioplasty vs riociguat in patients with inoperable chronic thromboembolic pulmonary hypertension: A systematic review and meta-analysis.

Wuwan Wang, Li Wen, Zhengdong Song, Wenhai Shi, Ke Wang, Wei Huang

Erratum issuedOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
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  13. Article
  14. Pulmonary endarterectomy.Indian journal of thoracic and cardiovascular surgery · 2021
    Review
  15. Review
  16. Review
  17. Balloon Pulmonary Angioplasty: State of the Art.Interventional cardiology (London, England) · 2020
    Review
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wuwan WangDepartment of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Li WenDepartment of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Zhengdong SongDepartment of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Wenhai ShiDepartment of Cardiology, The Sixth People's Hospital of Chengdu, Chengdu, China.
Ke WangInstitute of Cardiovascular Diseases of People's Liberation of Army (PLA), Xinqiao Hospital, Army Medical University, Chongqing, China.
Wei HuangDepartment of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-2707-2165
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNArmy Medical University · CNThe Sixth People's Hospital of Shenyang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsNo previous meta-analyses have compared the efficacy and safety of BPA with riociguat therapy in inoperable CTEPH patients.

methodsRelevant published studies were searched in the PubMed, Embase and ClinicalTrial.gov databases.

resultsTwenty-three clinical trials including 1454 patients (631 underwent BPA; 823 underwent riociguat therapy) were analyzed. BPA was associated with a greater improvement in RAP (mean difference (MD) = -3.53 mmHg, 95% CI: [-4.85, -2.21] vs MD = -1.05 mmHg, 95% CI: [-1.82, -0.29]); mPAP (MD = -15.02 mmHg, 95% CI: [-17.32, -12.71] vs MD = -4.19 mmHg, 95% CI: [-5.58, -2.80]); PVR (standard MD = -1.32 woods, 95% CI: [-1.57, -1.08] vs standard MD = -0.65 woods, 95% CI: [-0.79, -0.50]); NYHA functional class (RR = 6.78, 95% CI: [3.14, 14.64] vs RR = 1.49, 95% CI: [1.07, 2.07]); and 6MWD (MD = 71.66 m, 95% CI: [58.34, 84.99] vs MD = 45.25 m, 95% CI: [36.51, 53.99]) than riociguat treatment. However, the increase in CO was greater with riociguat (MD = 0.78 L/min, 95% CI: [0.61, 0.96]) than with BPA (MD = 0.33 L/min, 95% CI: [0.06, 0.59]). No significant difference in cardiac index (CI) was found between BPA (MD = 0.40 L/min/m

conclusionsOur meta-analysis indicates that BPA might be associated with greater improvements in exercise tolerance and pulmonary hemodynamics except for cardiac output and cardiac index than riociguat therapy. However, both of them were well tolerated.

Indexed as

Angioplasty, BalloonChronic DiseaseExercise ToleranceHumansHypertension, PulmonaryPulmonary ArteryPulmonary EmbolismPulmonary Wedge PressurePyrazolesPyrimidinesTreatment OutcomePyrazolesPyrimidinesriociguatballoon pulmonary angioplastychronic thromboembolic pulmonary hypertensionefficacyriociguatsafety

Identifiers

PMID31188483
PMCPMC6671827
OpenAlexW2951914098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.