ArticleThe Journal of clinical endocrinology and metabolism2019
Persistently Elevated PTH After Parathyroidectomy at One Year: Experience in a Tertiary Referral Center.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- American Association of Clinical Endocrinology Consensus Statement on Management of Multiple Endocrine Neoplasia Type 1.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025Guideline
- Elevated parathyroid hormone levels in normocalcemic patients after parathyroidectomy for primary hyperparathyroidism: what risk factors should be considered?BMC endocrine disorders · 2026Article
- Postoperative normocalcemic hyperparathyroidism: a comprehensive analysis of 510 cases.Turkish journal of medical sciences · 2026Article
- Predictors of Hungry Bone Syndrome After Parathyroidectomy in Secondary Hyperparathyroidism: A Narrative Review of Bone Turnover Biomarkers and Risk Prediction Tools.Journal of clinical medicine · 2025Review
- Analysis of Clinical and Biochemical Parameters and the Effectiveness of Surgical Treatment in Patients with Primary Hyperparathyroidism: A Single-Center Study.Journal of clinical medicine · 2025Article
- Predictors of persistently elevated parathyroid hormone levels after parathyroidectomy: experience from a reference center.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Case report: a rare case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma incidentally diagnosed in a 15-year-old girl.Frontiers in endocrinology · 2024Article
- Efficacy and safety of radiofrequency ablation for primary and secondary hyperparathyroidism: a retrospective study.Scientific reports · 2023Article
- The Eucalcemic Patient With Elevated Parathyroid Hormone Levels.Journal of the Endocrine Society · 2023Article
- Predicting ultrasound-guided thermal ablation benefit in primary hyperparathyroidism.European radiology · 2022Article
- Multiglandular Parathyroid Disease in Primary Hyperparathyroidism With Inconclusive Conventional Imaging.Physiological research · 2022Article
- European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.European journal of endocrinology · 2022Article
- Article
- [Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Review
- Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism.Frontiers in endocrinology · 2021Article
- Low 25-Hydroxyvitamin D in Primary Hyperparathyroidism: Enhanced Conversion Into 1,25-Hydroxyvitamin D May Not Be "True" Deficiency.JBMR plus · 2020Article
- Ectopic Parathyroid Adenoma in an 11-Year-Old Girl: Case Report and Literature Review.AACE clinical case reportsArticle
- A rare case of "Brown tumor" of the axis with parathyroid adenoma and tertiary hyperparathyroidism.Journal of craniovertebral junction & spineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
CONTEXT/
objectiveIncreased PTH after successful parathyroid surgery represents a clinical conundrum. We aimed to determine the prevalence of persistently elevated PTH (PePTH) postsurgery, along with predisposing factors.
designand Setting: Patients ≥ age 18 with parathyroidectomy performed at University of North Carolina Hospitals for primary hyperparathyroidism (PHPT) over a 12-year period were identified from the Carolina Data Warehouse. Clinical and demographic characteristics were collected, transformed, and analyzed.
resultsFive hundred seventy patients met initial criteria for PHPT, and of those 407 had postoperative values. One hundred forty-four had laboratory results within 3 to 18 months post operatively. There was no clinical difference between those with and without long-term laboratory follow-up. Presurgery, patients had average calcium of 11 mg/dL and PTH 125.4 pg/mL. Ninety-seven percent of patients had normalized calcium after surgery, but 30% had PePTH, which can be predicted at 3 months. Patients with PePTH (persistent elevation of PTH) after surgery did not differ from those with normalized PTH in terms of sex, age, body mass index, or excised gland weight; presurgery 25-vitamin D was slightly lower, but not abnormal (26 ± 15 vs 36 ± 11). The presurgical PTH was significantly higher (P < 0.001) in those with PePTH (156.5 pg/mL compared with presurgical level of 102.5 in those whose PTH normalized).
conclusionsNearly one-third of PHPT patients have elevated PTH levels postsurgery in a tertiary hospital setting. At presentation, patients with PePTH tend to have higher PTH relative to calcium levels. Whether PePTH after surgical treatment of PHPT has pathological consequences is unknown.
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