Evidence map›Paper›PMID 31188034›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.

Gunars Osis, Kierstin L Webster, Autumn N Harris, Hyun-Wook Lee, Chao Chen, Lijuan Fang, Michael F Romero, Ram B Khattri, Matthew E Merritt, Jill W Verlander and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Uncoupling proximal tubule ammoniagenesis from bicarbonate generation byAmerican journal of physiology. Renal physiology · 2026
    Article
  3. Review
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  5. Dietary baking soda (NaHCORenal failure · 2025
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  10. Article
  11. Article
  12. Article
  13. Isolated murine skeletal muscles utilize pyruvate over glucose for oxidation.Metabolomics : Official journal of the Metabolomic Society · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Expression of lactate dehydrogenase A and B isoforms in the mouse kidney.American journal of physiology. Renal physiology · 2021
    Article
  18. Article
  19. Tissue-SpecificMetabolites · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Gunars OsisDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Kierstin L WebsterDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Autumn N HarrisDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Hyun-Wook LeeDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Chao ChenDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Lijuan FangDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Michael F RomeroDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Ram B KhattriDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida.
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida.
Jill W VerlanderDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-4096-4897
I David WeinerDivision of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-0046-0600
University of Florida · USMayo Clinic · US

Funding

Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
H/HCO3 transport in the collecting ductR01DK045788 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2000 to 2017
$4.4M
Molecular Mechanisms Regulating Ammonia MetabolismR01DK107798 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2016 to 2025
$3.2M
Sex Differences in Renal Ammonia MetabolismK08DK120873 · NIDDK · UNIVERSITY OF FLORIDA · PI HARRIS, AUTUMN N · 2019 to 2023
$952k
NIDDK NIH HHS K08 DK120873NIDDK NIH HHS R01 DK045788NIDDK NIH HHS R01 DK107798NIDDK NIH HHS U24 DK097209
6 · The paper itself

Abstract

Citrate is critical for acid-base homeostasis and to prevent calcium nephrolithiasis. Both metabolic acidosis and hypokalemia decrease citrate excretion and increase expression of Na

Indexed as

AcidosisAnimalsCitratesDicarboxylic Acid TransportersDietFemaleGenetic VariationHypokalemiaImmunohistochemistryKidney MedullaMaleMiceMice, Inbred C57BLMice, KnockoutOrganic Anion Transporters, Sodium-DependentSymportersCitratesDicarboxylic Acid TransportersOrganic Anion Transporters, Sodium-DependentSlc13a2 protein, mouseSymporterscitrateNa+-dicarboxylate cotransporter 1proximal tubule

Identifiers

PMID31188034
PMCPMC6732450
OpenAlexW2951543103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.