Evidence map›Paper›PMID 31188016›Full record

ArticleAIDS patient care and STDs2019

Association of Gut Intestinal Integrity and Inflammation with Insulin Resistance in Adults Living with HIV in Uganda.

Michael J A Reid, Yifei Ma, Iya Golovaty, Samson Okello, Ruth Sentongo, Maggie Feng, Alexander C Tsai, Bernard Kakuhikire, Russell Tracy, Peter W Hunt and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS patient care and STDs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Michael J A Reid1 Department of Medicine, University of California, San Francisco, San Francisco, California.
Yifei Ma1 Department of Medicine, University of California, San Francisco, San Francisco, California.
Iya Golovaty1 Department of Medicine, University of California, San Francisco, San Francisco, California.
Samson Okello2 Mbarara University of Science and Technology, Mbarara, Uganda.
Ruth Sentongo2 Mbarara University of Science and Technology, Mbarara, Uganda.
Maggie Feng3 Massachusetts General Hospital, Boston, Massachusetts.
Alexander C Tsai2 Mbarara University of Science and Technology, Mbarara, Uganda.
Bernard Kakuhikire2 Mbarara University of Science and Technology, Mbarara, Uganda.
Russell Tracy5 University of Vermont, Burlington, Vermont.
Peter W Hunt1 Department of Medicine, University of California, San Francisco, San Francisco, California.
Mark Siedner2 Mbarara University of Science and Technology, Mbarara, Uganda.
Phyllis C Tien1 Department of Medicine, University of California, San Francisco, San Francisco, California.
University of California, San Francisco · USMbarara University of Science and Technology · UGMassachusetts General Hospital · USHarvard University · USUniversity of Vermont · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
The Center for the Global Demography of AgingP30AG024409 · NIA · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI BLOOM, DAVID E · 2004 to 2019
$7.9M
Developing Research At The Interface Of HIV And AgingR24AG044325 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HIGH, KEVIN P. · 2013 to 2017
$2.4M
Microenterprise to empower and improve health of HIV+ women in UgandaK23MH096620 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, ALEXANDER C · 2012 to 2016
$922k
Behavioral Aspects of Low-cost Medical Devices to Improve HIV CareK23MH099916 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2013 to 2017
$917k
Epidemiology of atherosclerosis among older-age individuals with HIV in UgandaR21HL124712 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2014 to 2015
$332k
NHLBI NIH HHS R21 HL124712NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI060354NIA NIH HHS P30 AG024409NIA NIH HHS R24 AG044325NIMH NIH HHS K23 MH096620NIMH NIH HHS K23 MH099916
6 · The paper itself

Abstract

We conducted a cross-sectional study of 148 HIV+ on HIV antiretroviral therapy and 149 HIV- adults in Mbarara, Uganda, to estimate the association between HIV infection and homeostasis model assessment of insulin resistance (HOMA-IR) using multivariable regression analysis. In addition, we evaluated whether intestinal fatty acid-binding protein (I-FABP), monocyte activation markers soluble (s)CD14 and sCD163, and proinflammatory cytokine interleukin 6 (IL-6) mediated this association. HOMA-IR was greater among HIV+ than HIV- adults [median (interquartile range): 1.3 (0.7-2.5) vs. 0.9 (0.5-2.4);

Indexed as

Fatty Acid-Binding ProteinsAdultAnti-Retroviral AgentsBiomarkersBody Mass IndexCase-Control StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlucose IntoleranceHIV InfectionsHIV SeronegativityHumansInflammationInsulin ResistanceMaleAnti-Retroviral AgentsBiomarkersFatty Acid-Binding Proteinsdiabetes mellitusHIVinsulin resistanceSub-Saharan Africa

Identifiers

PMID31188016
PMCPMC6602108
OpenAlexW2951984430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.