Evidence map›Paper›PMID 31187863›Full record

Trial reportThe Journal of nutrition2019

Docosahexaenoic and Arachidonic Acid Supplementation of Toddlers Born Preterm Does Not Affect Short-Term Growth or Adiposity.

Taniqua T Ingol, Rui Li, Kelly M Boone, Joseph Rausch, Mark A Klebanoff, Abigail Norris Turner, Keith O Yeates, Mary Ann Nelin, Kelly W Sheppard, Sarah A Keim

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02199808 (Fatty Acids and Executive Functions), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02199808 completednot on this map

Fatty Acids and Executive Functions: Cortical Activation and Behavioral Performance.

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2014 to 2016Enrolled79ConditionsExecutive Function
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Taniqua T IngolCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Rui LiCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Kelly M BooneSchoenbaum Family Center and Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, OH, USA.
Joseph RauschCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Mark A KlebanoffCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Abigail Norris TurnerDepartment of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA.
Keith O YeatesDepartment of Psychology, Alberta Children's Hospital Research Institute, and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Mary Ann NelinCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Kelly W SheppardCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Sarah A KeimCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Nationwide Children's Hospital · USThe Ohio State University · USUniversity of Calgary · CA

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
NCATS NIH HHS UL1 TR001070
6 · The paper itself

Abstract

backgroundDietary DHA intake among US toddlers is low. Healthy physical growth is an important objective for the clinical care of children born preterm.

objectivesThe aim of the trial was to examine the effects of supplementing toddlers born preterm with DHA and arachidonic acid (AA) for 180 d on growth and adiposity.

methodsOmega Tots, a randomized placebo-controlled trial, was conducted between April 2012 and March 2017. Children born at <35 wk gestation who were 10-16 mo in corrected age were assigned to receive daily oral supplements of DHA and AA (200 mg each, "DHA + AA") or corn oil (placebo) for 180 d. Prespecified secondary outcomes included weight, length, head circumference, mid-upper arm circumference, triceps and subscapular skinfolds, BMI, and their respective z scores, and body fat percentage, which were measured at baseline and trial completion. Mixed-effects regression was used to compare the change in outcomes between the DHA + AA and placebo groups, controlling for baseline values.

resultsAmong 377 children included in the analysis (median corrected age = 15.7 mo, 48.3% female), 348 (92.3%) had growth or adiposity data at baseline and trial end. No statistically significant differences between the DHA + AA and placebo groups in growth or adiposity outcomes were observed. For instance, the change in weight-for-age z scores was 0.1 for the DHA + AA group and 0.0 for the placebo group (effect size = 0.01, P = 0.99). However, post-hoc subgroup analyses revealed a statistically significant interaction between treatment group and sex, suggesting somewhat slower linear growth for females assigned to the DHA + AA group compared with the placebo group.

conclusionsAmong toddlers born preterm, daily supplementation with DHA + AA for 180 d resulted in no short-term differences in growth or adiposity compared with placebo. If DHA supplementation is implemented after the first year of life, it can be expected to have no effect on short-term growth or adiposity. This trial is registered with clinicaltrials.gov as NCT02199808.

Indexed as

Infant, PrematureAdiposityArachidonic AcidsDocosahexaenoic AcidsDouble-Blind MethodFemaleGrowthGuideline AdherenceHumansInfantInfant, NewbornMalePlacebosArachidonic AcidsDocosahexaenoic AcidsPlacebosadipositydocosahexaenoic acidgrowthinfantomega fatty acidspreterm birthtoddler

Identifiers

PMID31187863
PMCPMC7443757
OpenAlexW2949573864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.