Evidence map›Paper›PMID 31187746›Full record

ArticleThe Nigerian postgraduate medical journal

Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria.

Abdurrahman Elfulaty Ahmad, Adamu Girei Bakari, Bolanle Olufunke Priscilla Musa, Shettima Kagu Mustapha, Bello Yusuf Jamoh, Idris Nasir Abdullahi, Mohammed Ibrahim Tahir, Abdulqadri Olarenwaju Olatunji, Sumayya Hamza Maishanu, Ahmed Babangida Suleiman and 5 more

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In one paragraph

Article in The Nigerian postgraduate medical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Abdurrahman Elfulaty AhmadDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Adamu Girei BakariDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Bolanle Olufunke Priscilla MusaDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Shettima Kagu MustaphaDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Bello Yusuf JamohDepartment of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Idris Nasir AbdullahiDepartment of Medical Laboratory Science, Ahmadu Bello University, Zaria, Nigeria.
Mohammed Ibrahim TahirDepartment of Medical Laboratory Science, Ahmadu Bello University, Zaria, Nigeria.
Abdulqadri Olarenwaju OlatunjiResearch Unit, DNA LABS, Kaduna, Nigeria.
Sumayya Hamza MaishanuResearch Unit, DNA LABS, Kaduna, Nigeria.
Ahmed Babangida SuleimanDepartment of Microbiology, Ahmadu Bello University, Zaria, Nigeria.
Afolaranmi TolulopeDepartment of Community Medicine, University of Jos, Jos, Nigeria.
Claudia HawkinsDepartment of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Atiene Solomon SagayDepartment of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria.
Ayuba ZoakahDepartment of Community Medicine, University of Jos, Jos, Nigeria.
Adebola Tolulope OlayinkaDepartment of Medical Microbiology, Ahmadu Bello University, Zaria, Nigeria.

Funding

Support of Training and Mentoring in Nigeria for Academics (STAMINA)D43TW010130 · FIC · UNIVERSITY OF JOS · PI SAGAY, ATIENE SOLOMON · 2015 to 2019
$3.2M
FIC NIH HHS D43 TW010130
6 · The paper itself

Abstract

backgroundHepatitis B virus (HBV) is hyperendemic in Nigeria. Available literature reveal genotype E as being predominant in West Africa. This study aimed at identifying the current pattern and prevalent genotypes of HBV in Zaria, Nigeria. MATERIALS AND

methodsFour millilitre of blood was collected in ethylenediaminetetraacetic acid-container from each of 165 HBV surface antigen-positive participants recruited purposively from the gastroenterology clinic from May to August, 2017. Plasma was separated and frozen at -20°C till analysis. Multiplex-nested polymerase chain reaction using type-specific primers was used to identify the various HBV genotypes.

resultsMedian (and interquartile range) age of the participants was 31.0 (25.5-39.0) years, with males constituting 107 (64.8%). Majority (83.6%) of the samples analysed were HBV-DNA-positive with 82.6% of the HBV-DNA-positive samples being mixed genotype infections. Irrespective of mode of occurrence, five HBV genotypes were identified with HBV/E (97.1%) being the most predominant, followed by HBV/B (82.6%), HBV/A (24.6%), then HBV/C (17.4%), while HBV/D (0.7%) was the least prevalent.

conclusionIn most (99.1%) of the mixed-infection were a combination of genotype E, the predominant genotype, with other genotypes predominantly genotype B. HBV genotypes E, B, A, C and D are the prevalent genotypes in Zaria, Nigeria, as they occur in single genotype and in mixed-genotypes pattern.

Indexed as

DNA, ViralGenes, ViralGenotypeHepatitis BHepatitis B virusHumansMaleNigeriaPolymerase Chain ReactionPrevalenceDNA, ViralGenotypeshepatitis B Virusmixed-infectionNigeriaZaria

Identifiers

PMID31187746
PMCPMC6626198

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.