ArticleAging cell2019
Renormalized basal metabolic rate describes the human aging process and longevity.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Association of basal metabolic rate with mortality among cancer survivors: a cohort study emphasizing heterogeneity by gender and age.Annals of medicine · 2026Article
- Biological evidence of the life expectancy limit in human aging.GeroScience · 2026Article
- Exploring the Association Between Older Adults' Body Mass Index and Their Fall Experience, Chronic Diseases, and Exercise Frequency: Evidence from Korea.Medicina (Kaunas, Lithuania) · 2025Article
- Association between water intake and abdominal obesity: the Korea National Health and Nutrition Examination Survey 2019-2021.Korean journal of family medicine · 2025Article
- Association of predicted basal metabolic rate and insulin resistance in a Chinese general population.BMC endocrine disorders · 2025Article
- Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate.Scientific reports · 2025Article
- Body Fat and Visceral Fat Values in Spanish Healthcare Workers: Associated Variables.Nutrients · 2025Article
- Utilizing nutrition-related biomarkers to develop a nutrition-related aging clock for the chinese demographic.Frontiers in nutrition · 2025Article
- Article
- Skin Aging and the Upcoming Role of Ferroptosis in Geroscience.International journal of molecular sciences · 2024Review
- Lysophosphatidic Acid Receptor 3 Activation Is Involved in the Regulation of Ferroptosis.International journal of molecular sciences · 2024Article
- Human Ageing Genomic Resources: updates on key databases in ageing research.Nucleic acids research · 2024Article
- Selectively advantageous instability in biotic and pre-biotic systems and implications for evolution and aging.Frontiers in aging · 2024Review
- Modeling of age-related neurological disease: utility of zebrafish.Frontiers in aging neuroscience · 2024Review
- A Method for Real-Time Assessment of Mitochondrial Respiration Using Murine Corneal Biopsy.Investigative ophthalmology & visual science · 2023Article
- Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD).Journal of clinical medicine · 2021Article
- Energy Metabolism and Aging.The world journal of men's health · 2021Review
- Association Between Basal Metabolic Rate and All-Cause Mortality in a Prospective Cohort of Southern Chinese Adults.Frontiers in physiology · 2021Article
- Ferroptosis at the crossroads of infection, aging and cancer.Cancer science · 2020Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The question of why we age and finally die has been a central subject in the life, medical, and health sciences. Many aging theories have proposed biomarkers that are related to aging. However, they do not have sufficient power to predict the aging process and longevity. We here propose a new biomarker of human aging based on the mass-specific basal metabolic rate (msBMR). It is well known by the Harris-Benedict equation that the msBMR declines with age but varies among individual persons. We tried to renormalize the msBMR by primarily incorporating the body mass index into this equation. The renormalized msBMR (RmsBMR) which was derived in one cohort of American men (n = 25,425) was identified as one of the best biomarkers of aging, because it could well reproduce the observed respective American, Italian, and Japanese data on the mortality rate and survival curve. A recently observed plateau of the mortality rate in centenarians corresponded to the lowest value (threshold) of the RmsBMR, which stands for the final stage of human life. A universal decline of the RmsBMR with age was associated with the mitochondrial number decay, which was caused by a slight fluctuation of the dynamic fusion/fission system. This decay form was observed by the measurement in mice. Finally, the present approach explained the reason why the BMR in mammals is regulated by the empirical algometric scaling law.
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