Evidence map›Paper›PMID 31187572›Full record

ArticleInfluenza and other respiratory viruses2019

Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test.

Erin N Hodges, Vasiliy P Mishin, Juan De la Cruz, Zhu Guo, Ha T Nguyen, Eric Fallows, James Stevens, David E Wentworth, Charles Todd Davis, Larisa V Gubareva

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erin N HodgesInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.ORCID https://orcid.org/0000-0001-7298-6356
Vasiliy P MishinInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Juan De la CruzInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Zhu GuoInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Ha T NguyenInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Eric FallowsBecton, Dickinson and Company, Research Triangle Park, North Carolina.
James StevensInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
David E WentworthInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Charles Todd DavisInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Larisa V GubarevaInfluenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.ORCID https://orcid.org/0000-0002-4671-3079

Funding

Biomedical Advanced Research and Development Authority HHSO100201300008COffice of the Assistant Secretary for Preparedness and ResponseU.S. Department of Health and Human Services
6 · The paper itself

Abstract

Mutations in the influenza virus neuraminidase (NA) that cause reduced susceptibility to the NA inhibitor (NAI) oseltamivir may occur naturally or following antiviral treatment. Currently, detection uses either a traditional NA inhibition assay or gene sequencing to identify known markers associated with reduced inhibition by oseltamivir. Both methods are laborious and require trained personnel. The influenza antiviral resistance test (iART), a prototype system developed by Becton, Dickinson and Company for research use only, offers a rapid and simple method to identify such viruses. This study investigated application of iART to influenza A viruses isolated from non-human hosts with a variety of NA subtypes (N1-N9).

Indexed as

antiviral drugsavianinfluenza A virusresistancezoonotic

Identifiers

PMID31187572
PMCPMC6692545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.