ArticleHuman brain mapping2019
Evidence for genetic correlation between human cerebral white matter microstructure and inflammation.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Association between peripheral inflammation and free-water imaging in Major Depressive Disorder before and after ketamine treatment - A pilot study.Journal of affective disorders · 2022Trial
- White matter alterations in heart-kidney imbalance insomnia and Jiao-Tai-Wan treatment: A diffusion-tensor imaging study.Brain imaging and behavior · 2022Trial
- The causal relationship between immune cells, white matter microstructure and dementia: a Mendelian randomization study and co-localization analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Plasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.Neurobiology of aging · 2026Article
- Diffusion Tensor Imaging Magnetic Resonance Imaging Assessment in a Clinical Trial of Autologous Dendritic Cell Transfer for Diabetic Kidney Disease: A Molecular Approach.Diseases (Basel, Switzerland) · 2025Article
- Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water.Human brain mapping · 2025Article
- Beyond BMI: cardiometabolic measures as predictors of impulsivity and white matter changes in adolescents.Brain structure & function · 2023Article
- Serum Inflammatory Markers and Integrity of the Superior Longitudinal Fasciculus and the Inferior Longitudinal Fasciculus in Schizophrenia, from Prodromal Stages to Chronic Psychosis-A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Extended and replicated white matter changes in obesity: Voxel-based and region of interest meta-analyses of diffusion tensor imaging studies.Frontiers in nutrition · 2023Article
- Serum Inflammatory Markers and Their Associations with the Integrity of the Cingulum Bundle in Schizophrenia, from Prodromal Stages to Chronic Psychosis.Journal of clinical medicine · 2022Article
- Neurodegenerative model of schizophrenia: Growing evidence to support a revisit.Schizophrenia research · 2022Review
- Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Evidence for genetic correlation between human cerebral white matter microstructure and inflammation.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
White matter microstructure is affected by immune system activity via the actions of circulating pro-inflammatory cytokines. Although white matter microstructure and inflammatory measures are significantly heritable, it is unclear if overlapping genetic factors influence these traits in humans. We conducted genetic correlation analyses of these traits using randomly ascertained extended pedigrees from the Genetics of Brain Structure and Function Study (N = 1862, 59% females, ages 18-97 years; 42 ± 15.7). White matter microstructure was assessed using fractional anisotropy (FA) calculated from diffusion tensor imaging (DTI). Circulating levels (pg/mL) of pro-inflammatory cytokines (IL-6, IL-8, and TNFα) phenotypically associated with white matter microstructure were quantified from blood serum. All traits were significantly heritable (h
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