Evidence map›Paper›PMID 31187459›Full record

ReviewObesity surgery2019

Targeting Islets: Metabolic Surgery Is More than a Bariatric Surgery.

Xi Chen, Jingjing Zhang, Zhiguang Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Surgical Treatment of Type 2 Diabetes Mellitus in Youth.Advances in experimental medicine and biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xi ChenDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital and Diabetes Center, Institute of Metabolism and Endocrinology and National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, 410011, Hunan, China.
Jingjing ZhangDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital and Diabetes Center, Institute of Metabolism and Endocrinology and National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, 410011, Hunan, China.
Zhiguang ZhouDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital and Diabetes Center, Institute of Metabolism and Endocrinology and National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, 410011, Hunan, China. zhouzhiguang@csu.edu.cn.ORCID 0000-0001-7250-3588
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic surgery is an effective therapy for diabetic patients with obesity. The main mechanisms underlying the effects of metabolic surgery include food intake restriction and the accompanying reduced daily caloric intake and changes in gut hormones and bile acid. Insulin resistance and impaired β-cell function contribute to the development of type 2 diabetes. An increasing number of studies have focused on the central role of islet function in type 2 diabetes. In this article, we review the related high-quality literature and summarize the following mechanisms and principles underlying metabolic surgery in the context of islet function protection: (1) reduced glucotoxicity and chronic inflammation help facilitate better β-cell function and the preservation of β-cell mass following metabolic surgery; (2) based on the increased levels of GLP-1 and PYY after metabolic surgery, gut hormones appear to play a significant role in improving β-cell function through the GLP-1R signaling pathways; (3) the bile acid signaling pathway could affect β-cell function; and (4) the GLP-1R and bile acid signaling pathways could also cause other endocrine cells to contribute to islet function.

Indexed as

Bariatric SurgeryBile Acids and SaltsDiabetes Mellitus, Type 2Gastrointestinal HormonesHumansInsulin-Secreting CellsIslets of LangerhansObesityObesity, MorbidBile Acids and SaltsGastrointestinal HormonesIslet functionMechanismsMetabolic surgeryObesityType 2 diabetes mellitus

Identifiers

PMID31187459
OpenAlexW2951480783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.