Evidence map›Paper›PMID 31187451›Full record

ArticleImmunologic research2019

Catalase expression of Propionibacterium acnes may contribute to intracellular persistence of the bacterium in sinus macrophages of lymph nodes affected by sarcoidosis.

Kurara Yamamoto, Keisuke Uchida, Asuka Furukawa, Tomoki Tamura, Yuki Ishige, Mariko Negi, Daisuke Kobayashi, Takashi Ito, Tomoya Kakegawa, Akira Hebisawa and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Kurara YamamotoDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Keisuke UchidaDivision of Surgical Pathology, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Asuka FurukawaDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Tomoki TamuraDivision of Surgical Pathology, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Yuki IshigeDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Mariko NegiDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Daisuke KobayashiDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Takashi ItoDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Tomoya KakegawaDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Akira HebisawaClinical Research Center and Pathology Division, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose-si, Tokyo, 2048585, Japan.
Nobuyasu AwanoDivision of Clinical Respiratory Medicine, Japanese Red Cross Medical Center, 4-1-22 Hiro-o, Shibuya-ku, Tokyo, 1508935, Japan.
Tamiko TakemuraDivision of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiro-o, Shibuya-ku, Tokyo, 1508935, Japan.
Tomonari AmanoDivision of Pathology, Tokyo Kita Medical Center, 4-17-56 Akabanedai, Kita-ku, Tokyo, 115-0053, Japan.
Takumi AkashiDivision of Surgical Pathology, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan.
Yoshinobu EishiDepartment of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138510, Japan. eishi.path@tmd.ac.jp.ORCID http://orcid.org/0000-0002-0521-1670
Tokyo Medical and Dental University · JPTokyo Medical and Dental University Hospital · JPJapanese Red Cross Medical Center · JPTokyo-Kita Medical Center · JPTokyo National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial catalase is important for intracellular survival of the bacteria. This protein of Propionibacterium acnes, one of possible causes of sarcoidosis, induces hypersensitive Th1 immune responses in sarcoidosis patients. We examined catalase expression in cultured P. acnes isolated from 19 sarcoid and 18 control lymph nodes and immunohistochemical localization of the protein in lymph nodes from 43 sarcoidosis and 102 control patients using a novel P. acnes-specific antibody (PAC) that reacts with the catalase protein, together with the previously reported P. acnes-specific PAB and TIG antibodies. High catalase expression of P. acnes cells was found during stationary phase in more isolates from sarcoid than from non-sarcoid lymph nodes and was associated with bacterial survival under H

Indexed as

Gene ExpressionAdultAgedAntibodies, BacterialAntibody SpecificityBacteriaBiopsyCatalaseFemaleFluorescent Antibody TechniqueHumansImmunohistochemistryLymph NodesMacrophagesMaleMiddle AgedAntibodies, BacterialCatalaseCatalaseMonoclonal antibodyPropionibacterium acnesSarcoidosis

Identifiers

PMID31187451
OpenAlexW2949990498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.