Evidence map›Paper›PMID 31187426›Full record

ArticleInternational urology and nephrology2019

The predictive value of Klotho polymorphism, in addition to classical markers of CKD-MBD, for left ventricular hypertrophy in haemodialysis patients.

Branislav Apostolović, Tatjana Cvetković, Nikola Stefanović, Svetlana Apostolović, Marija Anđelković Apostolović, Branka Mitić, Radmila Veličković Radovanović, Karolina Paunović, Aleksandra Ignjatović, Mina Cvetković and 2 more

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In one paragraph

Article in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed, 3 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Branislav ApostolovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia. bane.apostolovic@gmail.com.ORCID http://orcid.org/0000-0002-1464-833X
Tatjana CvetkovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Nikola StefanovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Svetlana ApostolovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Marija Anđelković ApostolovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Branka MitićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Radmila Veličković RadovanovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Karolina PaunovićClinic of Nephrology, Clinical Center Niš, Niš, Serbia.
Aleksandra IgnjatovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Mina CvetkovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Nataša StevićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
Dusica PavlovićFaculty of Medicine, University of Niš, Bul. dr Zorana Djindjića 81, 1800, Niš, Serbia.
University of Nis · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCardiovascular events are the major reasons for mortality in haemodialysis patients. Fibroblast growth factor 23 (FGF23), Klotho protein and G-395A Klotho gene polymorphism have been associated with effects on the cardiovascular system. Our study investigates the interrelationship between Klotho protein gene variations, mineral-bone metabolism and left ventricular hypertrophy in patients undergoing chronic haemodialysis programme. MATERIALS AND

methodsPatients (n = 142) were genotyped for G-395A Klotho gene. Components of mineral-bone metabolism, classical and non-classical (FGF23, Klotho and vitamin D) as well as echocardiographic examination were determined. Predictive models were designed to determine the significance of Klotho gene variations and mineral-bone metabolism components for left ventricle hypertrophy (LVH).

resultsA-allele carriers were longer on haemodialysis (p = 0.033), and had higher phosphorus levels (p = 0.016) while the level of Klotho protein was significantly lower (p = 0.001) compared to non-A-allele carriers. The best gains were achieved upon addition of allele A, and all three new markers; the AUC made significant improvement from 0.596 to 0.806 (p < 0.001), and improved net reclassification for 82.1% (95% CI 42.9-121.3%).

conclusionsThe genetic background of A-allele carriers of the G-395A Klotho gene polymorphism increases the susceptibility patients to haemodialysis. A-allele carriers are at a higher risk for the development of cardiovascular complications. The addition of non-classical to classical mineral metabolism components improves prediction power to LVH.

Indexed as

Polymorphism, GeneticRenal DialysisAgedChronic Kidney Disease-Mineral and Bone DisorderCohort StudiesFemaleFibroblast Growth Factor-23GlucuronidaseHumansHypertrophy, Left VentricularKlotho ProteinsMaleMiddle AgedPredictive Value of TestsFGF23 protein, humanFibroblast Growth Factor-23GlucuronidaseKlotho ProteinsFGF23HaemodialysisKlothoKlotho gene polymorphismLVHPredictive models

Identifiers

PMID31187426
OpenAlexW2951494820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.