ArticleJournal of neurology2019
Regional variation in the incidence rate and sex ratio of multiple sclerosis in Scotland 2010-2017: findings from the Scottish Multiple Sclerosis Register.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Methods of estimating prevalence of multiple sclerosis in six European healthcare data sources: a contribution from the ConcePTION project.European journal of epidemiology · 2026Article
- Global and Regional Trends in Multiple Sclerosis Incidence with Projections to 2030: A Joinpoint Regression Analysis of the GBD Data 2021 by Socio-Demographic Index and WHO Regions.Annals of global health · 2026Article
- Identifying multiple sclerosis in women of childbearing age in six European countries: a contribution from the ConcePTION project.European journal of epidemiology · 2025Article
- The Canadian collaborative project on genetic susceptibility to multiple sclerosis cohort population structure and disease etiology.Frontiers in neurology · 2025Article
- Multiple sclerosis: emerging epidemiological trends and redefining the clinical course.The Lancet regional health. Europe · 2024Review
- 'There's Nothing Wrong With You; You Just Need to Lose Weight'-A Qualitative Exploration of Pelvic Floor Dysfunction Among Women With Multiple Sclerosis and Their Interaction in Seeking Pelvic Healthcare.Health expectations : an international journal of public participation in health care and health policy · 2024Article
- Prevalence and Burden of Multiple Sclerosis in China, 1990-2019: Findings From the Global Burden of Disease Study 2019.Neurology · 2024Article
- Cellular and Molecular Evidence of Multiple Sclerosis Diagnosis and Treatment Challenges.Journal of clinical medicine · 2023Review
- Immune Cell Contributors to the Female Sex Bias in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.Current topics in behavioral neurosciences · 2023Article
- VIKING II, a worldwide observational cohort of volunteers with northern isles ancestry.International journal of population data science · 2023Observational
- FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis.BMJ open · 2022Observational
- Multiple sclerosis epidemiological trends in Italy highlight the environmental risk factors.Journal of neurology · 2022Review
- Rationale and design of the brain magnetic resonance imaging protocol for FutureMS: a longitudinal multi-centre study of newly diagnosed patients with relapsing-remitting multiple sclerosis in Scotland.Wellcome open research · 2022Article
- Regarding: High Correlations Among Worldwide Prevalences of Dementias, Parkinson's Disease, Multiple Sclerosis and Motor Neuron Diseases Indicate Common Causative Factors.Neuroscience insights · 2022Article
- Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients.Advances in experimental medicine and biology · 2022Article
- Prediction of Multiple sclerosis disease using machine learning classifiers: a comparative study.Journal of preventive medicine and hygiene · 2021Article
- Prevalence and Incidence of Multiple Sclerosis in Russian Federation: 30 Years of Studies.Brain sciences · 2020Review
- Impact of the first COVID-19 pandemic wave on the Scottish Multiple Sclerosis Register population.Wellcome open research · 2020Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundFifteen regional studies published over the last six decades surveying prevalence, mortality and hospital admissions have suggested that Scotland is amongst the highest risk nations for multiple sclerosis (MS) in the world. However, substantial intranational variation in rates (between regions) has been described in numerous countries, including in the only previous Scottish national survey, which used hospital admission data, to address this issue. Against this backdrop, the Scottish Multiple Sclerosis Register (SMSR) was established in 2010 to prospectively collect nationally comprehensive incidence data and to allow for regional comparisons.
methodsHere, we present the SMSR and analyse the variation in crude and age-sex standardized incidence rates, lifetime risk (cumulative incidence), and the sex distribution of cases and rates, between the 14 administrative Health Boards or regions of Scotland: 01 January 2010 to 31 December 2017.
resultsThe overall incidence rate for Scotland was 8.76/100,000 person-years (standardized: 8.54). Regional incidence rates varied significantly-up to threefold-between Health Boards (p < 1 × 10
conclusionsThis study introduces a national incidence register: a valuable research tool and the result of substantial public investment. The wide variation in incidence rates and sex ratios between regions, in a relatively homogenous population, raises questions for future study.
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