Evidence map›Paper›PMID 31187187›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice.

Kunal Khurana, Nitin Bansal

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kunal KhuranaI. K. Gujral Punjab Technical University, Kapurthala, Punjab, 144603, India.
Nitin BansalDepartment of Pharmacology, ASBASJSM College of Pharmacy, Bela (Ropar), Punjab, 140111, India. nitindsp@rediffmail.com.ORCID 0000-0002-2792-7469
Hindu College of Pharmacy · INPunjab Technical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a serious medical illness displaying high lifetime prevalence, early-age onset that adversely affects socio-economic status. The bidirectional association between oxidative stress and calcium-signaling adversely affects the monoaminergic neuron functions that instigate the pathogenesis of depression. The present study investigates the effect of lacidipine (LCD), L-type Ca

Indexed as

AnimalsAntidepressive AgentsBehavior, AnimalBrainCalcium Channel BlockersDepressionDihydropyridinesDisease Models, AnimalDose-Response Relationship, DrugFemaleHindlimb SuspensionMaleMiceNitrosative StressOxidative StressReserpineAntidepressive AgentsCalcium Channel BlockersDihydropyridineslacidipineReserpineCalcium channelDepressionLacidipineOxidative stressReserpine

Identifiers

PMID31187187
OpenAlexW2953336279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.