ArticleVirchows Archiv : an international journal of pathology2019
Mist1: a novel nuclear marker for acinic cell carcinoma of the salivary gland.
Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Regional atrophy, cellular plasticity, and regenerative potential in irradiated murine salivary glands.Acta oncologica (Stockholm, Sweden) · 2025Article
- Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland.Discover oncology · 2025Article
- Low-Dose Paracetamol Treatment Protects Neuronal Oxidative Stress and Neuroinflammation in D-Galactose-Induced Accelerated Aging Model.Scientifica · 2025Article
- Alterations in histology of the aging salivary gland and correlation with the glandular inflammatory microenvironment.iScience · 2023Article
- Xerostomia and Its Cellular Targets.International journal of molecular sciences · 2023Review
- Salivary gland function, development, and regeneration.Physiological reviews · 2022Review
- Establishment of prognostic risk model and drug sensitivity based on prognostic related genes of esophageal cancer.Scientific reports · 2022Article
- DDX56 transcriptionally activates MIST1 to facilitate tumorigenesis of HCC through PTEN-AKT signaling.Theranostics · 2022Article
- Expression Analysis of MIST1 and EMT Markers in Primary Tumor Samples Points to MIST1 as a Biomarker of Cervical Cancer.International journal of general medicine · 2021Article
- Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway.Journal of Cancer · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Muscle, intestine, and stomach expression 1 (Mist1) is a transcription factor that functions in the development of granule organisation in serous exocrine cells of the gastrointestinal tract. The aim of this study was to investigate whether Mist1 can be used as a marker for acinic cell carcinoma (AciCC) of the salivary gland. Immunohistochemistry (IHC) was used to analyse Mist1 expression in AciCC (n = 26), secretory carcinoma (SC; n = 18) and 12 other types of salivary gland tumours (n = 99). Strong Mist1 staining was observed in normal serous acinar cells and plasma cells. Mist1 was diffusely expressed in AciCC, with the immunostaining intensity ranging from moderate (4/26) to strong (22/26). Most SC specimens were either negative (7/18) or focally and mildly positive (9/18) for Mist1. Only two SC cases demonstrated a moderate level of Mist1 staining. When moderate-to-strong Mist1 staining was used as the criterion of positivity, all the tested salivary gland tumours other than AciCC were negative for Mist1, except for two cases of SC. Previously cut tissue sections and decalcified specimens exhibited reduced Mist1 immunostaining intensity, which may give false-negative results. In summary, Mist1 is a sensitive marker for serous acinar cells of salivary glands and AciCC, and background non-tumour acinar cells and plasma cells can serve as good internal positive controls.
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