Evidence map›Paper›PMID 31187155›Full record

ArticleThe Journal of membrane biology2019

Solid-State NMR Investigations of the MHC II Transmembrane Domains: Topological Equilibria and Lipid Interactions.

Christopher Aisenbrey, Evgeniy S Salnikov, Burkhard Bechinger

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of membrane biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Unraveling membrane properties at the organelle-level with LipidDyn.Computational and structural biotechnology journal · 2022
    Article
  4. Review
  5. Article
  6. Magnetic Alignment of Polymer Nanodiscs Probed by Solid-State NMR Spectroscopy.Langmuir : the ACS journal of surfaces and colloids · 2020
    Article
  7. Article
  8. Review
  9. Special Issue: Membrane and Receptor Dynamics.The Journal of membrane biology · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher AisenbreyInstitut de Chimie, Université de Strasbourg/CNRS, UMR7177, 4, Rue Blaise Pascal, 67070, Strasbourg, France.
Evgeniy S SalnikovInstitut de Chimie, Université de Strasbourg/CNRS, UMR7177, 4, Rue Blaise Pascal, 67070, Strasbourg, France.
Burkhard BechingerInstitut de Chimie, Université de Strasbourg/CNRS, UMR7177, 4, Rue Blaise Pascal, 67070, Strasbourg, France. bechinge@unistra.fr.ORCID 0000-0001-5719-6073

Funding

Agence Nationale de la Recherche 10-BLAN-731Agence Nationale de la Recherche 10-LABX-0026_CSCAgence Nationale de la Recherche 12-BSV5-0012Agence Nationale de la Recherche 14-CE34-0001-01Agence Nationale de la Recherche 15-CE11-0017-01
6 · The paper itself

Abstract

The major histocompatibility complex class II (MHC II) membrane proteins are key players in the adaptive immune response. An aberrant function of these molecules is associated with a large number of autoimmune diseases such as diabetes type I and chronic inflammatory diseases. The MHC class II is assembled from DQ alpha 1 and DQ beta 1 which come together as a heterodimer through GXXXG-mediated protein-protein interactions and a highly specific protein-sphingomyelin-C18 interaction motif located on DQA1. This association can have important consequences in regulating the function of these membrane proteins. Here, we investigated the structure and topology of the DQA1 and DQB1 transmembrane helical domains by CD-, oriented

Indexed as

Amino Acid MotifsHLA-DQ alpha-ChainsHLA-DQ beta-ChainsHumansLipid BilayersNuclear Magnetic Resonance, BiomolecularPhosphatidylcholinesProtein Domains1-palmitoyl-2-oleoylphosphatidylcholineHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQB1 antigenHLA-DQ beta-ChainsLipid BilayersPhosphatidylcholinesFatty acyl chain order parameterHelix topologyHighly specific protein–lipid interactionSolid-state NMRSupported lipid bilayerTransmembrane dimer

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.