Evidence map›Paper›PMID 31187137›Full record

SynthesisThe journals of gerontology. Series B, Psychological sciences and social sciences2021

A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults.

Andrea R Zammit, Andrea M Piccinin, Emily C Duggan, Andriy Koval, Sean Clouston, Annie Robitaille, Cassandra L Brown, Philipp Handschuh, Chenkai Wu, Valérie Jarry and 15 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journals of gerontology. Series B, Psychological sciences and social sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Predicting the onset of dementia with longitudinal performance-based measures of physical function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Andrea R ZammitSaul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Andrea M PiccininDepartment of Psychology, University of Victoria, Canada.
Emily C DugganDepartment of Psychology, University of Victoria, Canada.
Andriy KovalDepartment of Psychology, University of Victoria, Canada.
Sean CloustonDepartment of Family, Population and Preventive Medicine, Stony Brook University, New York.
Annie RobitailleDepartment of Psychology, Université du Québec à Montréal, Canada.
Cassandra L BrownDepartment of Psychology, University of Victoria, Canada.
Philipp HandschuhDepartment of Developmental Psychology, Institute of Psychology and Education, Ulm University, Germany.
Chenkai WuGlobal Health Research Center, Duke Kunshan University, China.
Valérie JarryResearch Center on Aging, Integrated Academic Health Center and Social Services in the Eastern Townships, Sherbrooke, Canada.
Deborah FinkelDepartment of Psychology, Indiana University Southeast, New Albany.
Raquel B GrahamDepartment of Psychology, University of Victoria, Canada.
Graciela Muniz-TerreraCentre for Dementia Prevention, University of Edinburgh, UK.
Marcus Praetorius BjörkDepartment of Psychology, University of Gothenburg, Sweden.
David BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Dorly J DeegDepartment of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands.
Boo JohanssonDepartment of Psychology, University of Gothenburg, Sweden.
Mindy J KatzSaul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Jeffrey KayeDepartment of Neurology, Oregon Health & Science University, Portland.
Richard B LiptonSaul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.
Mike MartinDepartment of Psychology, University of Zurich, Switzerland.
Nancy L PedersonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Avron SpiroDepartment of Psychiatry, Boston University School of Medicine, Massachusetts.
Daniel ZimprichDepartment of Developmental Psychology, Institute of Psychology and Education, Ulm University, Germany.
Scott M HoferDepartment of Psychology, University of Victoria, Canada.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Richard B. LIPTON · 1985 to 2026
$73.9M
Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Statistical Data EnclaveP30AG012846 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI A. FREEDMAN · 1999 to 2026
$23.2M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Study Coordination and Measurement CoreP01AG043362 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HOFER, SCOTT M. · 2013 to 2017
$7.8M
Evaluation of Multivariate Causal Factors Linking the Flynn Effect to Declining Dementia Trends and Cognitive AgingR01AG067621 · NIA · PACIFIC HEALTH RESEARCH/ EDUCATION INST · PI HOFER, SCOTT M. · 2019 to 2023
$3.6M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
Application of latent and integrative approaches to understand the spectrum of cognitive agingK01AG054700 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ZAMMIT, ANDREA ROSE · 2017 to 2021
$653k
NCATS NIH HHS UL1 TR001073NIA NIH HHS K01 AG054700NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG043362NIA NIH HHS P30 AG012846NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG017644NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG067621NIA NIH HHS U01 AG009740NIH HHS 2RO1AG7644NIH HHS AG04563NIH HHS AG08861
6 · The paper itself

Abstract

objectiveHandgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used to generate new longitudinal results based on comparable construct-level measurements and identical statistical models and to facilitate replication and research synthesis.

methodsWe performed coordinated analysis on 9 cohort studies affiliated with the Integrative Analysis of Longitudinal Studies of Aging and Dementia (IALSA) research network. Bivariate linear mixed models were used to examine associations among individual differences in baseline level, rate of change, and occasion-specific variation across grip strength and indicators of cognitive function, including mental status, processing speed, attention and working memory, perceptual reasoning, verbal ability, and learning and memory. Results were summarized using meta-analysis.

resultsAfter adjustment for covariates, we found an overall moderate association between change in grip strength and change in each cognitive domain for both males and females: Average correlation coefficient was 0.55 (95% CI = 0.44-0.56). We also found a high level of heterogeneity in this association across studies. DISCUSSION: Meta-analytic results from nine longitudinal studies showed consistently positive associations between linear rates of change in grip strength and changes in cognitive functioning. Future work will benefit from the examination of individual patterns of change to understand the heterogeneity in rates of aging and health-related changes across physical and cognitive biomarkers.

Indexed as

AgingCognitive DysfunctionHand StrengthAgedCognitionFemaleGeriatric AssessmentHumansIntelligence TestsLongitudinal StudiesMaleRisk AssessmentCognitive functionCoordinated analysisGrip strengthHarmonizationIntegrative data analysisLongitudinal studies

Identifiers

PMID31187137
PMCPMC7813182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.