ArticleLab on a chip2019
Ultra-compact, automated microdroplet radiosynthesizer.
Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Droplet-Based Radiosynthesis and High-Throughput Optimization of Vinyl Sulfone Prosthetic Group ([Molecules (Basel, Switzerland) · 2026Article
- Rapid Concentration of Ga-68 and Proof-of-Concept Microscale Labeling of [Molecules (Basel, Switzerland) · 2024Article
- Scalable droplet-based radiosynthesis of [Lab on a chip · 2024Article
- Microfluidic-based production of [EJNMMI radiopharmacy and chemistry · 2023Article
- Alpha Particle-Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery.Molecular imaging and biology · 2023Review
- Proof-of-concept optimization of a copper-mediatedLab on a chip · 2023Article
- Accelerating radiochemistry development: Automated robotic platform for performing up to 64 droplet radiochemical reactions in a morning.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysisAnalytical methods : advancing methods and applications · 2023Article
- A rapid and systematic approach for the optimization of radio thin-layer chromatography resolution.Journal of chromatography. A · 2023Article
- Rapid Purification and Formulation of Radiopharmaceuticals via Thin-Layer Chromatography.Molecules (Basel, Switzerland) · 2022Article
- Discovery, nuclear properties, synthesis and applications of technetium-101.Communications chemistry · 2022Review
- Economical Production of Radiopharmaceuticals for Preclinical Imaging Using Microdroplet Radiochemistry.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Economical droplet-based microfluidic production of [Scientific reports · 2021Article
- Article
- Optimization of Radiochemical Reactions using Droplet Arrays.Journal of visualized experiments : JoVE · 2021Article
- Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals.Frontiers in physics · 2021Article
- A simple and efficient automated microvolume radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2020Article
- Multi-GBq production of the radiotracer [RSC advances · 2020Article
- Green and efficient synthesis of the radiopharmaceutical [Reaction chemistry & engineering · 2020Article
- On-demand radiosynthesis ofRSC advances · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Application of microfluidics offers numerous advantages in the field of radiochemistry and could enable dramatic reductions in the cost of producing radiotracers for positron emission tomography (PET). Droplet-based microfluidics, in particular, requires only microgram quantities of expensive precursors and reagents (compared to milligram used in conventional radiochemistry systems), and occupies a more compact footprint (potentially eliminating the need for specialized shielding facilities, i.e. hot cells). However, the reported platforms for droplet radiosynthesis have several drawbacks, including high cost/complexity of microfluidic reactors, requirement for manual intervention (e.g. for adding reagents), or difficulty in precise control of droplet processes. We describe here a platform based on a particularly simple chip, where reactions take place atop a hydrophobic substrate patterned with a circular hydrophilic liquid trap. The overall supporting hardware (heater, rotating carousel of reagent dispensers, etc.) is very simple and the whole system could be packaged into a very compact format (about the size of a coffee cup). We demonstrate the consistent synthesis of [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.