Evidence map›Paper›PMID 31186972›Full record

ArticleCase reports in dermatological medicine2019

Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study.

Rajasekar Seetharaman, Anjum Mahmood, Prashant Kshatriya, Divyang Patel, Anand Srivastava

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in dermatological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review.Clinical, cosmetic and investigational dermatology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rajasekar SeetharamanGIOSTAR Research Inc. Pvt. Ltd., Ahmedabad, Gujrat, India.
Anjum MahmoodGIOSTAR Research Inc. Pvt. Ltd., Ahmedabad, Gujrat, India.
Prashant KshatriyaGIOSTAR Research Inc. Pvt. Ltd., Ahmedabad, Gujrat, India.
Divyang PatelGIOSTAR Research Inc. Pvt. Ltd., Ahmedabad, Gujrat, India.
Anand SrivastavaGIOSTAR Research Inc. Pvt. Ltd., Ahmedabad, Gujrat, India.ORCID 0000-0002-5805-9801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis, an autoimmune disease, affects a vast number of peoples around the world. In this report, we discuss our findings about a scalp psoriasis suffering patient with a Psoriasis Scalp Severity Index (PSSI) score of 28, who was treated with Mesenchymal stem cell conditioned media (MSC-CM). Remarkably, complete regression was recorded within a treatment period of one month only (PSSI score of 0). A number of bioactive factors like cytokines and growth factors secreted by MSCs in the conditioned medium are very likely to be the principle molecules which play a vital role in skin regeneration. Treatment using MSC-CM appears to be an effective tool for tackling the psoriatic problem and, thus, may offer a new avenue of therapy which could be considered as an alternative approach to overcome the limitations of the cell-based therapy.

Identifiers

PMID31186972
PMCPMC6521531

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.