ArticleOncology letters2019
Circular RNA ATXN7 is upregulated in non-small cell lung cancer and promotes disease progression.
Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The role of circular RNAs (circRNAs) as a prognostic factor in lung cancer: a meta-analysis.BMC cancer · 2024Pooled it
- Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p.Thoracic cancer · 2022Article
- Expression of CircATXN7 in esophageal cancer tissues and its effect on cell proliferation and invasion.Journal of gastrointestinal oncology · 2022Article
- The Molecular Basis of Spinocerebellar Ataxia Type 7.Frontiers in neuroscience · 2022Review
- Serum long non‑coding RNA NNT‑AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR‑496/RAP2C axis in colorectal cancer.Molecular medicine reports · 2021Article
- Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives.Frontiers in oncology · 2021Review
- Insights Into circRNAs: Functional Roles in Lung Cancer Management and the Potential Mechanisms.Frontiers in cell and developmental biology · 2021Review
- Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4.Cancer cell international · 2020Article
- A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress.Journal of molecular cell biology · 2019Article
- Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway.Cancer cell international · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that is generated from back-splicing, and is characterized by a covalent closed loop without 3' and 5' ends. Recently, the biological function of circRNAs has received increasing attention; however, studies on circRNAs in non-small cell lung cancer (NSCLC) have rarely been reported. In the present study, the expression profiles of circRNAs in NSCLC were investigated, and the association between the circular RNA ATXN7 (circATXN7) expression level and clinicopathological characteristics of patients with NSCLC was assessed. In addition, the effects of circATXN7 on cell proliferation and invasion were examined. The results revealed that circATXN7 was upregulated in 45 NSCLC tissues compared with its expression in non-tumor tissues. However, there was no marked difference between the expression level of circATXN7 and the majority of the examined clinicopathological characteristics. It was also observed that the survival time of patients with high circATXN7 levels was shorter compared with that of patients with low circATXN7 levels, although the difference was not statistically significant (P>0.05). Furthermore, silencing of circATXN7 by small interfering RNA inhibited the proliferation and invasion of NSCLC cells
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