ReviewEvidence-based complementary and alternative medicine : eCAM2019
Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review.
Review in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Coordinate-based (ALE) meta-analysis of acupuncture for musculoskeletal pain.Frontiers in neuroscience · 2022Pooled it
- Trial
- Electroacupuncture and P2X receptors: purinergic mechanisms in pain modulation : A narrative review with structured evidence mapping.Purinergic signalling · 2026Review
- Decoding Pancreatic Cancer Pain: From Tumor-Nerve Crosstalk to Targeted Analgesic Strategies.International journal of medical sciences · 2026Review
- Acupuncture for the Management of Postpartum Uterine Contraction Pain Following Vaginal Delivery: A Protocol for a Randomized, Sham-Controlled Trial.Journal of pain research · 2026Article
- Article
- Acupuncture protects against ischemic stroke by inhibiting the NF-κB pathway.IBRO neuroscience reports · 2025Article
- Recent advances in osteoarthritis research: A review of treatment strategies, mechanistic insights, and acupuncture.Medicine · 2025Review
- Electroacupuncture for Refractory Chronic Pelvic Pain: A Case Report with 24-Month Follow-Up.International journal of women's health · 2025Article
- Peripheral Rho-associated protein kinase activation mediates acupuncture analgesia.Integrative medicine research · 2024Article
- Meta-analysis and sequential analysis of acupuncture compared to carbamazepine in the treatment of trigeminal neuralgia.World journal of clinical cases · 2024Article
- Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli (ST36) in mice.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Electroencephalographic insights into the pathophysiological mechanisms of emergence delirium in children and corresponding clinical treatment strategies.Frontiers in pharmacology · 2024Review
- Transcutaneous electrical acupoint stimulation in adult patients receiving gastrectomy/colorectal resection: A randomized controlled trial.World journal of gastrointestinal surgery · 2023Article
- Effectiveness of Integrative Korean Medicine Treatment in Patients with Traffic-Accident-Induced Acute Low Back Pain and Mild Adult Scoliosis.Healthcare (Basel, Switzerland) · 2023Article
- Analgesic Efficacy of Acupuncture on Chronic Pelvic Pain: A Systemic Review and Meta-Analysis Study.Healthcare (Basel, Switzerland) · 2023Review
- Acupuncture as multi-targeted therapy for the multifactorial disease obesity: a complex neuro-endocrine-immune interplay.Frontiers in endocrinology · 2023Review
- Diachronic analysis of major acupoints used in ancient and current acupuncture treatments: Changes in main acupoints over time.Integrative medicine research · 2022Article
- Acupressure versus parecoxib sodium in acute renal colic: A prospective cohort study.Frontiers in medicine · 2022Article
- Acupuncture Alleviates Menstrual Pain in Rat Model via Suppressing Eotaxin/CCR3 Axis to Weak EOS-MC Activation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsDespite the wide use of acupuncture for the management of visceral pain and the growing interest in the pathophysiology of visceral pain, there is no conclusive elucidation of the mechanisms behind the effects of acupuncture on visceral pain. This systematic review aims to provide an integrative understanding of the treatment mechanism of acupuncture for visceral pain.
methodsElectronic and hand searches were conducted to identify studies that involved visceral pain and acupuncture.
resultsWe retrieved 192 articles, out of which 46 studies were included in our review. The results of our review demonstrated that visceral pain behaviors were significantly alleviated in response to acupuncture treatment in groups treated with this intervention compared to in sham acupuncture or no-treatment groups. Changes in the concentrations of
conclusionsAcupuncture reduced visceral pain behavior and induced significant changes in neuronal activity as well as in the levels of pain/inflammation-related cytokines and neurotransmitters in the brain-gut axis. Further researches on the thalamus and on a standard animal model are warranted to improve our knowledge on the mechanism of acupuncture that facilitates visceral pain modulation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.