SynthesisGenetics in medicine : official journal of the American College of Medical Genetics2019
Delivering genomic medicine in the United Kingdom National Health Service: a systematic review and narrative synthesis.
Synthesis in Genetics in medicine : official journal of the American College of Medical Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An innovative framework to determine the implementation level of personalized medicine: A systematic review.Frontiers in public health · 2023Pooled it
- Consanguineous Marriage: Law and Public Health.Health care analysis : HCA : journal of health philosophy and policy · 2025Article
- Current landscape of clinical genetics knowledge and attitudes among Non-Geneticist Physicians - the McGill genetics education survey (McGES).Journal of community genetics · 2025Article
- From tradition to transformation: evolving models of care in clinical genetics.Current opinion in pediatrics · 2025Review
- A roadmap for genome projects to foster psychosocial and economic evidence to further policy and practice.Communications medicine · 2025Review
- Egypt Genome: Towards an African new genomic era.Journal of advanced research · 2025Review
- Integration of genomic medicine to mainstream patient care within the UK National Health Service.The Ulster medical journal · 2024Review
- The Egypt Genome Project.Nature genetics · 2024Article
- QALYs and rare diseases: exploring the responsiveness of SF-6D, EQ-5D-5L and AQoL-8D following genomic testing for childhood and adult-onset rare genetic conditions in Australia.Health and quality of life outcomes · 2023Article
- Uptake of funded genomic testing for syndromic and non-syndromic intellectual disability in Australia.European journal of human genetics : EJHG · 2023Article
- Enhancing Data Protection in Dynamic Consent Management Systems: Formalizing Privacy and Security Definitions with Differential Privacy, Decentralization, and Zero-Knowledge Proofs.Sensors (Basel, Switzerland) · 2023Article
- The implementation of large-scale genomic screening or diagnostic programmes: A rapid evidence review.European journal of human genetics : EJHG · 2023Review
- "A very big challenge": a qualitative study to explore the early barriers and enablers to implementing a national genomic medicine service in England.Frontiers in genetics · 2023Article
- Genomic sequencing in oncology: Considerations for integration in routine cancer care.European journal of cancer care · 2022Article
- Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy.European heart journal. Cardiovascular pharmacotherapy · 2022Article
- Myocardial ultrastructure can augment genetic testing for sporadic dilated cardiomyopathy with initial heart failure.ESC heart failure · 2021Article
- Anticipating the primary care role in genomic medicine: expectations of genetics health professionals.Journal of community genetics · 2021Article
- Patients' and professionals' views related to ethical issues in precision medicine: a mixed research synthesis.BMC medical ethics · 2021Review
- A Web Screening on Educational Initiatives to Increase Citizens' Literacy on Genomics and Genetics.Frontiers in genetics · 2021Article
- Oncologist-Reported Reasons for Not Ordering Multimarker Tumor Panels: Results From a Nationally Representative Survey.JCO precision oncology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
purposeWe sought to assess the readiness of the United Kingdom (UK) National Health Service to implement a Genomic Medicine Service. We conducted a systematic literature review to identify what is known about factors related to the implementation of genomic medicine in routine health care and to draw out the implications for the UK and other settings.
methodsRelevant studies were identified in Web of Science and PubMed from their date of inception to April 2018. The review included primary research studies using quantitative, qualitative, or mixed methods, and systematic reviews. A narrative synthesis was conducted.
resultsFifty-five studies met our inclusion criteria. The majority of studies reviewed were conducted in the United States. We identified four domains: (1) systems, (2) training and workforce needs, (3) professional attitudes and values, and (4) the role of patients and the public.
conclusionMainstreaming genomic medicine into routine clinical practice requires actions at each level of the health-care system. Our synthesis emphasized the organizational, social, and cultural implications of reforming practice, highlighting that demonstration of clinical utility and cost-effectiveness, attending to the compatibility of genomic medicine with clinical principles, and involving and engaging patients are key to successful implementation.
Indexed as
Identifiers
31186523What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.