ArticleScientific reports2019
Leukocyte telomere length, lipid parameters and gestational diabetes risk: a case-control study in a Chinese population.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Telomere Length in Patients with Gestational Diabetes Mellitus and Normoglycemic Pregnant Women: a Systematic Review and Meta-analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Shortening Leukocyte Telomere Length Associated With Elevated Blood Diabetes-Related Cardiovascular Risk Factor in Thai Adolescents.Food science & nutrition · 2025Article
- Associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- The relationship between telomere length and aging-related diseases.Clinical and experimental medicine · 2025Review
- Univariable and multivariable Mendelian randomization investigating the effects of telomere length on the risk of adverse pregnancy outcomes.Frontiers in endocrinology · 2023Article
- NHHR: An Important Independent Risk Factor for Patients with STEMI.Reviews in cardiovascular medicine · 2022Article
- Which one of LDL-C /HDL-C ratio and non-HDL-C can better predict the severity of coronary artery disease in STEMI patients.BMC cardiovascular disorders · 2022Article
- Cardiometabolic profile and leukocyte telomere length in a Black South African population.Scientific reports · 2022Article
- Prevalence and risk factors of diabetic retinopathy among Chinese adults with type 2 diabetes in a suburb of Shanghai, China.PloS one · 2022Article
- Effect of high-quality nursing service in the delivery room on puerperae and newborns.American journal of translational research · 2022Article
- Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis.Scientific reports · 2020Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of genomic DNA extracted from peripheral blood leukocytes was measured using quantitative polymerase chain reaction (qPCR). Odds ratios (OR) and 95% confidence interval (CI) of GDM risk were calculated across tertiles of RTL using logistic regression model. Lipid parameters during the third trimesters of gestation (after 32 weeks) were collected from medical records. The general linear correlation test was used to explore the associations of lipid parameters with RTL. Our results showed that the RTL in GDM patients were significantly shorter than controls (0.302 ± 0.112 vs. 0.336 ± 0.164, P = 0.046). However, the GDM risk was significantly increased in subjects with median RTL (adjusted OR [aOR]: 1.936, 95% CI: 1.086, 3.453, P = 0.025) and the shortest RTL (aOR: 1.795, 95% CI: 1.004, 3.207, P = 0.048), compared to subjects with longest RTL. We also demonstrated that the lipid ratios (TC/TG, LDL/TG, HDL/TG, LDL/TC, TC/LDL) were significantly associated with RTL among controls. Overall, the present study indicated that attrition of telomeres would increase GDM risk among pregnant women, and the altered lipid levels may play an important role in RTL related GDM risk and pathogenesis.
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