ArticleScientific reports2019
Auditory Steady State Response; nature and utility as a translational science tool.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.Schizophrenia bulletin · 2024Pooled it
- Enhanced 40 and 80 Hz Auditory Steady State Responses in Patients with Idiopathic Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Disruption of brain rhythms in a pharmacological model of schizophrenia in male and female mice.Biology of sex differences · 2025Article
- The Application of Gamma-Range Auditory Steady-State Responses in Animal Models: A Semi-Structured Literature Review.Brain sciences · 2025Review
- The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures.Schizophrenia (Heidelberg, Germany) · 2025Article
- Auditory steady-state response deficits in Fragile X Syndrome implicate deficits in stimulus representation maintenance and GABAergic modulation.medRxiv : the preprint server for health sciences · 2025Article
- Network resonance and the auditory steady state response.Scientific reports · 2024Article
- Transcranial Alternating Current Stimulation Alters Auditory Steady-State Oscillatory Rhythms and Their Cross-Frequency Couplings.Clinical EEG and neuroscience · 2024Article
- Gamma-band harmonic responses for beta-band auditory steady-state response are intact in patients with early stage schizophrenia.Neuropsychopharmacology reports · 2024Article
- Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques.BMC neuroscience · 2022Article
- Psilocybin-Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience.Journal of personalized medicine · 2022Article
- Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade.Psychopharmacology · 2021Article
- Mismatch negativity as EEG biomarker supporting CNS drug development: a transnosographic and translational study.Translational psychiatry · 2021Article
- Neural network dynamics underlying gamma synchronization deficits in schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Hitting The Right Spot: NMDA Receptors in the Auditory Thalamus May Hold the Key to Understanding Schizophrenia.The international journal of neuropsychopharmacology · 2020Article
- A distributed frontotemporal network underlies gamma-band synchronization impairments in schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome.Scientific reports · 2020Article
- High-density EEG of auditory steady-state responses during stimulation of basal forebrain parvalbumin neurons.Scientific data · 2020Article
- Aberrant Auditory Steady-State Response of Awake Mice After Single Application of the NMDA Receptor Antagonist MK-801 Into the Medial Geniculate Body.The international journal of neuropsychopharmacology · 2020Article
- Effects of (+)-bicuculline, a GABAa receptor antagonist, on auditory steady state response in free-moving rats.PloS one · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology of ASSR recording from the brain surface has not been standardized in preclinical studies, limiting its use as a translational biomarker. The sites of maximal ASSR in humans are the vertex and/or middle frontal area, although it has been suggested that the auditory cortex is the source of the ASSR. We constructed and validated novel methods for ASSR recording using a switchable pedestal which allows ASSR recording alternatively from temporal or parietal cortex with a wide range of frequencies in freely moving rats. We further evaluated ASSR as a translational tool by assessing the effect of ketamine. The ASSR measured at parietal cortex did not show clear event-related spectral perturbation (ERSP) or inter-trial coherence (ITC) in any frequency bands or a change with ketamine. In contrast, the ASSR at temporal cortex showed clear ERSP and ITC where 40 Hz was maximal in both gamma-band frequencies. Ketamine exerted a biphasic effect in ERSP at gamma bands. These findings suggest that temporal cortex recording with a wide frequency range is a robust methodology to detect ASSR, potentially enabling application as a translational biomarker in psychiatric and developmental disorders.
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