Evidence map›Paper›PMID 31186486›Full record

ArticleScientific reports2019

A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development.

Gerald Hahn, Michael A Skeide, Dante Mantini, Marco Ganzetti, Alain Destexhe, Angela D Friederici, Gustavo Deco

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gerald HahnCenter for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, 08018, Barcelona, Spain. gerald.hahn@upf.edu.
Michael A SkeideDepartment of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103, Leipzig, Germany.
Dante MantiniResearch Center for Motor Control and Neuroplasticity, KU Leuven, 3001, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6485-5559
Marco GanzettiResearch Center for Motor Control and Neuroplasticity, KU Leuven, 3001, Leuven, Belgium.
Alain DestexheUnit for Neurosciences, Information and Complexity (UNIC), CNRS, 91190, Gif-sur-Yvette, France and The European Institute for Theoretical Neuroscience (EITN), 75012, Paris, France.
Angela D FriedericiDepartment of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103, Leipzig, Germany.
Gustavo DecoCenter for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, 08018, Barcelona, Spain.

Funding

Wellcome Trust 101253/Z/13/Z
6 · The paper itself

Abstract

Recently introduced effective connectivity methods allow for the in-vivo investigation of large-scale functional interactions between brain regions. However, dynamic causal modeling, the most widely used technique to date, typically captures only a few predefined regions of interest. In this study, we present an alternative computational approach to infer effective connectivity within the entire connectome and show its performance on a developmental cohort with emerging language capacities. The novel approach provides new opportunities to quantify effective connectivity changes in the human brain.

Indexed as

Computer SimulationLanguage DevelopmentAdolescentAdultBrainChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleNerve NetYoung Adult

Identifiers

PMID31186486
PMCPMC6559954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.