ArticleScientific reports2019
Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
- K-Edge imaging using a clinical dual-source photon-counting CT system.Journal of applied clinical medical physics · 2026Article
- Lumen imaging in calcified coronary arteries using high-resolution Gd-enhanced color K-edge imaging with spectral photon-counting CT: a phantom study.European radiology experimental · 2026Article
- Photon-Counting Detector Computed Tomography and Hepatocellular Carcinoma-A Systematic Review of the Current Evidence.Diagnostics (Basel, Switzerland) · 2026Review
- A Hybrid Approach Combining Dual-Energy and Inpainting Methods for Metal Artifact Reduction in Dentomaxillofacial CBCT: A Proof-of-Concept Phantom Study.Annals of biomedical engineering · 2025Article
- Technical performance of dual-contrast-agent K-edge imaging with four energy thresholds on a commercial photon counting detector CT.Medical physics · 2025Article
- Advances in Ultrasmall Inorganic Nanoparticles for Nanomedicine: From Diagnosis to Therapeutics.ACS applied materials & interfaces · 2025Review
- Beam hardening of K-edge contrast agents: a phantom study comparing clinical energy-integrating detector and photon-counting detector CT systems.European radiology experimental · 2025Article
- Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage.Scientific reports · 2024Article
- In Regards to Baubeta et al. JACMP 25(4), e14324.Journal of applied clinical medical physics · 2024Article
- A Novel and Reliable Pixel Response Correction Method (DAC-Shifting) for Spectral Photon-Counting CT Imaging.Tomography (Ann Arbor, Mich.) · 2024Article
- No gadolinium K-edge detected on the first clinical photon-counting computed tomography scanner.Journal of applied clinical medical physics · 2024Article
- Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future.Radiology · 2023Review
- Spectral CT: Current Liver Applications.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Structural and functional imaging of brains.Science China. Chemistry · 2023Review
- Imaging in translational cancer research.Cancer biology & medicine · 2022Review
- Ytterbium Nanoparticle Contrast Agents for Conventional and Spectral Photon-Counting CT and Their Applications for Hydrogel Imaging.ACS applied materials & interfaces · 2022Article
- Spectral Photon-Counting Computed Tomography: A Review on Technical Principles and Clinical Applications.Journal of imaging · 2022Review
- Hepatic dual-contrast CT imaging: slow triple kVp switching CT with CNN-based sinogram completion and material decomposition.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- An Overview of X-ray Photon Counting Spectral Imaging (x-CSI) with a Focus on Gold Nanoparticle Quantification in Oncology.Journal of imaging · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnostic imaging of hepatocellular carcinoma (HCC) requires a liver CT or MRI multiphase acquisition protocol. Patients would benefit from a high-resolution imaging method capable of performing multi-phase imaging in a single acquisition without an increase in radiation dose. Spectral Photon-Counting Computed Tomography (SPCCT) has recently emerged as a novel and promising imaging modality in the field of diagnostic radiology. SPCCT is able to distinguish between two contrast agents referred to as multicolor imaging because, when measuring in three or more energy regimes, it can detect and quantify elements with a K-edge in the diagnostic energy range. Based on this capability, we tested the feasibility of a dual-contrast multi-phase liver imaging protocol via the use of iodinated and gadolinated contrast agents on four healthy New Zealand White (NZW) rabbits. To perform a dual-contrast protocol, we injected the agents at different times so that the first contrast agent visualized the portal phase and the second the arterial phase, both of which are mandatory for liver lesion characterization. We demonstrated a sensitive discrimination and quantification of gadolinium within the arteries and iodine within the liver parenchyma. In the hepatic artery, the concentration of gadolinium was much higher than iodine (8.5 ± 3.9 mg/mL versus 0.7 ± 0.1 mg/mL) contrary to the concentrations found in the liver parenchyma (0.5 ± 0.3 mg/mL versus 4.2 ± 0.3 mg/mL). In conclusion, our results confirm that SPCCT allows in-vivo dual contrast qualitative and quantitative multi-phase liver imaging in a single acquisition.
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