Evidence map›Paper›PMID 31186427›Full record

ArticleNature communications2019

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Darina Czamara, Gökçen Eraslan, Christian M Page, Jari Lahti, Marius Lahti-Pulkkinen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  4. Research Review: Developmental origins of depression - a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2021
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Darina CzamaraMax-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, 80804, Germany.ORCID http://orcid.org/0000-0001-7381-904X
Gökçen EraslanInstitute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0001-9579-2909
Christian M PageOslo Centre for Biostatistics and Epidemiology, Research Support Unit, Oslo University Hospital, Oslo, 0372, Norway.ORCID http://orcid.org/0000-0002-1897-3666
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Marius Lahti-PulkkinenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.ORCID http://orcid.org/0000-0002-5244-5525
Esa HämäläinenHUSLAB and Department of Clinical Chemistry, Helsinki University, Helsinki, 00290, Finland.
Eero KajantieOulu University Hospital and University of Oulu, PEDEGO Research Unit, MRC Oulu, 90014, Finland.
Hannele LaivuoriMedical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital, Helsinki, 00014, Finland.ORCID http://orcid.org/0000-0003-3212-7826
Pia M VillaMedical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital, Helsinki, 00014, Finland.
Rebecca M ReynoldsBritish Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Wenche NystadDepartment of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, 0213, Norway.
Siri E HåbergCenter for Fertility and Health, Norwegian Institute of Public Health, Oslo, 0213, Norway.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, 20814, USA.ORCID http://orcid.org/0000-0003-4911-5290
Kieran J O'DonnellLudmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, H3A 2B4, QC, Canada.
Elika GargLudmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, H3A 2B4, QC, Canada.ORCID http://orcid.org/0000-0002-3093-7940
Michael J MeaneyLudmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, H3A 2B4, QC, Canada.
Sonja EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, 10117, Germany.
Pathik D WadhwaUniversity of California, Irvine, Development, Health, and Disease Research Program, Orange, CA, 92697, USA.
Claudia BussCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, 10117, Germany.ORCID http://orcid.org/0000-0002-8738-3133
Meaghan J JonesCentre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children's Hospital Research Institute, Vancouver, V5Z 4H4, BC, Canada.
David T S LinCentre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children's Hospital Research Institute, Vancouver, V5Z 4H4, BC, Canada.ORCID http://orcid.org/0000-0001-5695-9446
Julie L MacIsaacCentre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children's Hospital Research Institute, Vancouver, V5Z 4H4, BC, Canada.
Michael S KoborCentre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children's Hospital Research Institute, Vancouver, V5Z 4H4, BC, Canada.
Nastassja KoenDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, 7925, South Africa.
Heather J ZarDepartment of Paediatrics & Child Health and SAMRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, 7505, South Africa.
Karestan C KoenenDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.
Shareefa DalvieDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, 7925, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, 7925, South Africa.
Ivan KondoferskyInstitute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Nikola S MüllerInstitute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Fabian J TheisInstitute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0002-2419-1943
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Katri RäikkönenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
Elisabeth B BinderMax-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, 80804, Germany. binder@psych.mpg.de.

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Intergenerational Effects of Maternal Childhood Trauma on the Fetal BrainR01MH105538 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, FAIR, DAMIEN A · 2015 to 2019
$3.5M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
GENETIC AND ENVIRONMENTAL FACTORS IN CHILDHOOD RESPIRATORY HEALTHZ01ES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1996 to 2008
$537k
Maternal Traumatic Stress and Child Development: Epigenetic LinksR21HD085849 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI KOENEN, KARESTAN C, STEIN, DAN JOSEPH · 2015 to 2016
$323k
Intramural NIH HHS Z01 ES049019Medical Research Council G0700704Medical Research Council MC_UU_00007/10Medical Research Council MR/K026992/1Medical Research Council MR/L010305/1Medical Research Council MR/L023784/2NICHD NIH HHS R01 HD060628NICHD NIH HHS R21 HD085849NIEHS NIH HHS N01 ES075558NIH HHS S10 OD018164NIMH NIH HHS R01 MH105538NIMH NIH HHS U01 MH109536NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

Indexed as

Gene-Environment InteractionCohort StudiesDNADNA MethylationEpigenesis, GeneticFemaleFetal BloodGenotypeHumansInfant, NewbornMalePregnancyRisk FactorsDNA

Identifiers

PMID31186427
PMCPMC6559955

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.