ArticleNature communications2019
Learning of distant state predictions by the orbitofrontal cortex in humans.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Interactions between human orbitofrontal cortex and hippocampus support model-based inference.PLoS biology · 2020Trial
- Article
- Long-term Learning Induces Plastic Changes in Frontostriatal Circuits.bioRxiv : the preprint server for biology · 2026Article
- Building Goal-Directed Cognitive Graphs.bioRxiv : the preprint server for biology · 2026Article
- Predictive encoding of auditory sequences in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Neural evidence that humans reuse strategies to solve new tasks.PLoS biology · 2025Article
- Disentangling the Component Processes in Complex Planning Impairments Following Ventromedial Prefrontal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Diminished State Space Theory of Human Aging.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Article
- The brain hierarchically represents the past and future during multistep anticipation.Nature communications · 2024Article
- Consolidation Enhances Sequential Multistep Anticipation but Diminishes Access to Perceptual Features.Psychological science · 2024Article
- The brain hierarchically represents the past and future during multistep anticipation.bioRxiv : the preprint server for biology · 2024Article
- Heuristics in risky decision-making relate to preferential representation of information.Nature communications · 2024Article
- Forming cognitive maps for abstract spaces: the roles of the human hippocampus and orbitofrontal cortex.Communications biology · 2024Article
- Traveling waves shape neural population dynamics enabling predictions and internal model updating.bioRxiv : the preprint server for biology · 2024Article
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
- Trait anxiety is associated with hidden state inference during aversive reversal learning.Nature communications · 2023Article
- Task state representations in vmPFC mediate relevant and irrelevant value signals and their behavioral influence.Nature communications · 2023Article
- Review
- Confidence modulates the decodability of scene prediction during partially-observable maze exploration in humans.Communications biology · 2022Article
- Predictive Representations in Hippocampal and Prefrontal Hierarchies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Representations of our future environment are essential for planning and decision making. Previous research in humans has demonstrated that the hippocampus is a critical region for forming and retrieving associations, while the medial orbitofrontal cortex (OFC) is an important region for representing information about recent states. However, it is not clear how the brain acquires predictive representations during goal-directed learning. Here, we show using fMRI that while participants learned to find rewards in multiple different Y-maze environments, hippocampal activity was highest during initial exposure and then decayed across the remaining repetitions of each maze, consistent with a role in rapid encoding. Importantly, multivariate patterns in the OFC-VPFC came to represent predictive information about upcoming states approximately 30 s in the future. Our findings provide a mechanism by which the brain can build models of the world that span long-timescales to make predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.