ArticleJournal of musculoskeletal & neuronal interactions2019
Association between structural changes in brain with muscle function in sarcopenic older women: the women's healthy ageing project (WHAP).
Article in Journal of musculoskeletal & neuronal interactions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Protocol for a prospective cohort study for the assessment of sarcopenia in gestational diabetes: the SiGnal-D study.BMJ open · 2026Article
- Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study.GeroScience · 2025Article
- Casual associations between brain structure and sarcopenia: A large-scale genetic correlation and mendelian randomization study.Aging cell · 2024Article
- Interactions between muscle volume and body mass index on brain structure in the UK Biobank.Frontiers in dementia · 2024Article
- Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe involvement of changes in brain structure in the pathophysiology of muscle loss (sarcopenia) with aging remains unclear. In this study, we investigated the associations between brain structure and muscle strength in a group of older women. We hypothesized that structural changes in brain could correlate with functional changes observed in sarcopenic older women.
methodsIn 150 women (median age of 70 years) of the Women's Healthy Ageing Project (WHAP) Study, brain grey (total and cortex) volumes were calculated using magnetic resonance imaging (MRI) analyses. Grip strength and timed up and go (TUG) were measured. The brain volumes were compared between sarcopenic vs. non-sarcopenic subjects and women with previous falls vs. those without.
resultsBased on handgrip strength and TUG results respectively, 27% and 15% of women were classified as sarcopenic; and only 5% were sarcopenic based on both criteria. At least one fall was experienced by 15% of participants. There was no difference in brain volumetric data between those with vs. without sarcopenia (p>0.24) or between women with falls (as a symptom of weakness or imbalance) vs. those without history of falls (p>0.25).
conclusionsBrain structure was not associated with functional changes or falls in this population of older women.
Indexed as
Identifiers
31186383PMC6587084What OpenQuestion holds
Registered trials
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